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GDF15 Induces Anorexia through Nausea and Emesis.
Borner T, Shaulson ED, Ghidewon MY, Barnett AB, Horn CC, Doyle RP, Grill HJ, Hayes MR, De Jonghe BC. Borner T, et al. Among authors: de jonghe bc. Cell Metab. 2020 Feb 4;31(2):351-362.e5. doi: 10.1016/j.cmet.2019.12.004. Epub 2020 Jan 9. Cell Metab. 2020. PMID: 31928886 Free PMC article.
A second-generation glucagon-like peptide-1 receptor agonist mitigates vomiting and anorexia while retaining glucoregulatory potency in lean diabetic and emetic mammalian models.
Borner T, Shaulson ED, Tinsley IC, Stein LM, Horn CC, Hayes MR, Doyle RP, De Jonghe BC. Borner T, et al. Among authors: de jonghe bc. Diabetes Obes Metab. 2020 Oct;22(10):1729-1741. doi: 10.1111/dom.14089. Epub 2020 Jun 25. Diabetes Obes Metab. 2020. PMID: 32410372 Free PMC article.
Central mechanisms of emesis: A role for GDF15.
Borner T, Pataro AM, De Jonghe BC. Borner T, et al. Among authors: de jonghe bc. Neurogastroenterol Motil. 2024 Aug 6:e14886. doi: 10.1111/nmo.14886. Online ahead of print. Neurogastroenterol Motil. 2024. PMID: 39108013 Review.
Corrination of a GLP-1 Receptor Agonist for Glycemic Control without Emesis.
Borner T, Workinger JL, Tinsley IC, Fortin SM, Stein LM, Chepurny OG, Holz GG, Wierzba AJ, Gryko D, Nexø E, Shaulson ED, Bamezai A, Da Silva VAR, De Jonghe BC, Hayes MR, Doyle RP. Borner T, et al. Among authors: de jonghe bc. Cell Rep. 2020 Jun 16;31(11):107768. doi: 10.1016/j.celrep.2020.107768. Cell Rep. 2020. PMID: 32553160 Free PMC article.
Design and Evaluation of Peptide Dual-Agonists of GLP-1 and NPY2 Receptors for Glucoregulation and Weight Loss with Mitigated Nausea and Emesis.
Milliken BT, Elfers C, Chepurny OG, Chichura KS, Sweet IR, Borner T, Hayes MR, De Jonghe BC, Holz GG, Roth CL, Doyle RP. Milliken BT, et al. Among authors: de jonghe bc. J Med Chem. 2021 Jan 28;64(2):1127-1138. doi: 10.1021/acs.jmedchem.0c01783. Epub 2021 Jan 15. J Med Chem. 2021. PMID: 33449689 Free PMC article.
58 results