An LK - Search Results

1

Topoisomerase 1 Regulates Gene Expression in Neurons through Cleavage Complex-Dependent and -Independent Mechanisms.

Mabb AM, Simon JM, King IF, Lee HM, An LK, Philpot BD, Zylka MJ. Mabb AM, et al. Among authors: an lk. PLoS One. 2016 May 27;11(5):e0156439. doi: 10.1371/journal.pone.0156439. eCollection 2016. PLoS One. 2016. PMID: 27231886 Free PMC article.

2

Synthesis and antiproliferative activity of indolizinophthalazine-5,12-dione derivatives, DNA topoisomerase IB inhibitors.

Shen DQ, Wu ZP, Wu XW, An ZY, Bu XZ, Gu LQ, Huang ZS, An LK. Shen DQ, et al. Among authors: an zy, an lk. Eur J Med Chem. 2010 Sep;45(9):3938-42. doi: 10.1016/j.ejmech.2010.05.048. Epub 2010 Jun 1. Eur J Med Chem. 2010. PMID: 20638158

3

A novel DNA topoisomerase I inhibitor with different mechanism from camptothecin induces G2/M phase cell cycle arrest to K562 cells.

Wu N, Wu XW, Agama K, Pommier Y, Du J, Li D, Gu LQ, Huang ZS, An LK. Wu N, et al. Among authors: an lk. Biochemistry. 2010 Nov 30;49(47):10131-6. doi: 10.1021/bi1009419. Epub 2010 Nov 8. Biochemistry. 2010. PMID: 21033700 Free PMC article.

4

Synthesis and biological evaluation of benzo[a]phenazine derivatives as a dual inhibitor of topoisomerase I and II.

Zhuo ST, Li CY, Hu MH, Chen SB, Yao PF, Huang SL, Ou TM, Tan JH, An LK, Li D, Gu LQ, Huang ZS. Zhuo ST, et al. Among authors: an lk. Org Biomol Chem. 2013 Jun 28;11(24):3989-4005. doi: 10.1039/c3ob40325d. Org Biomol Chem. 2013. PMID: 23657605

5

Synthesis and biological evaluation of 6-substituted indolizinoquinolinediones as catalytic DNA topoisomerase I inhibitors.

Yu LM, Zhang XR, Li XB, Yang Y, Wei HY, He XX, Gu LQ, Huang ZS, Pommier Y, An LK. Yu LM, et al. Among authors: an lk. Eur J Med Chem. 2015 Aug 28;101:525-33. doi: 10.1016/j.ejmech.2015.07.007. Epub 2015 Jul 8. Eur J Med Chem. 2015. PMID: 26188908 Free PMC article.

6

Synthesis, cytotoxicity and structure-activity relationship of indolizinoquinolinedione derivatives as DNA topoisomerase IB catalytic inhibitors.

Yu Q, Yang H, Zhu TW, Yu LM, Chen JW, Gu LQ, Huang ZS, An LK. Yu Q, et al. Among authors: an lk. Eur J Med Chem. 2018 May 25;152:195-207. doi: 10.1016/j.ejmech.2018.04.040. Epub 2018 Apr 22. Eur J Med Chem. 2018. PMID: 29705710

7

Discovery, Synthesis, and Evaluation of Oxynitidine Derivatives as Dual Inhibitors of DNA Topoisomerase IB (TOP1) and Tyrosyl-DNA Phosphodiesterase 1 (TDP1), and Potential Antitumor Agents.

Zhang XR, Wang HW, Tang WL, Zhang Y, Yang H, Hu DX, Ravji A, Marchand C, Kiselev E, Ofori-Atta K, Agama K, Pommier Y, An LK. Zhang XR, et al. Among authors: an lk. J Med Chem. 2018 Nov 21;61(22):9908-9930. doi: 10.1021/acs.jmedchem.8b00639. Epub 2018 Oct 31. J Med Chem. 2018. PMID: 30336023 Free PMC article.

8

The antitumor activity of CYB-L10, a human topoisomerase IB catalytic inhibitor.

Yu Q, Chen Y, Yang H, Zhang HL, Agama K, Pommier Y, An LK. Yu Q, et al. Among authors: an lk. J Enzyme Inhib Med Chem. 2019 Dec;34(1):818-822. doi: 10.1080/14756366.2018.1516651. J Enzyme Inhib Med Chem. 2019. PMID: 30907213 Free PMC article.

9

Synthesis and biological evaluation of 5-aminoethyl benzophenanthridone derivatives as DNA topoisomerase IB inhibitors.

Tang WL, Zhang Y, Hu DX, Yang H, Yu Q, Chen JW, Agama K, Pommier Y, An LK. Tang WL, et al. Among authors: an lk. Eur J Med Chem. 2019 Sep 15;178:81-92. doi: 10.1016/j.ejmech.2019.05.074. Epub 2019 May 30. Eur J Med Chem. 2019. PMID: 31176097 Free PMC article.

10

Secondary metabolites from Isodon ternifolius (D. Don) Kudo and their anticancer activity as DNA topoisomerase IB and Tyrosyl-DNA phosphodiesterase 1 inhibitors.

Zhang HL, Zhang Y, Yan XL, Xiao LG, Hu DX, Yu Q, An LK. Zhang HL, et al. Among authors: an lk. Bioorg Med Chem. 2020 Jun 1;28(11):115527. doi: 10.1016/j.bmc.2020.115527. Epub 2020 Apr 22. Bioorg Med Chem. 2020. PMID: 32345458

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