Tetraspanin-2 promotes glucotoxic apoptosis by regulating the JNK/β-catenin signaling pathway in human pancreatic β cells.
Hwang IH, Park J, Kim JM, Kim SI, Choi JS, Lee KB, Yun SH, Lee MG, Park SJ, Jang IS.
Hwang IH, et al. Among authors: kim jm, kim si.
FASEB J. 2016 Sep;30(9):3107-16. doi: 10.1096/fj.201600240RR. Epub 2016 May 31.
FASEB J. 2016.
PMID: 27247127
Free PMC article.
High TSPAN2 levels up-regulated phosphorylated (p) JNK and induced apoptosis. p-JNK enhanced the phosphorylation of beta-catenin and Dickkopf-1 (Dkk1). Dkk1 knockdown by small interfering (si)RNA up-regulated nuclear beta-catenin, suggesting that it is a JNK/beta-catenin-d …
High TSPAN2 levels up-regulated phosphorylated (p) JNK and induced apoptosis. p-JNK enhanced the phosphorylation of beta-catenin and Dickkop …