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Discovery of indole inhibitors of chemokine receptor 9 (CCR9).
Pandya BA, Baber C, Chan A, Chamberlain B, Chandonnet H, Goss J, Hopper T, Lippa B, Poutsiaka K, Romero J, Stucka S, Varoglu M, Zhang J, Zhang X. Pandya BA, et al. Among authors: zhang j, zhang x. Bioorg Med Chem Lett. 2016 Jul 15;26(14):3322-3325. doi: 10.1016/j.bmcl.2016.05.043. Epub 2016 May 14. Bioorg Med Chem Lett. 2016. PMID: 27256913
In-silico guided discovery of novel CCR9 antagonists.
Zhang X, Cross JB, Romero J, Heifetz A, Humphries E, Hall K, Wu Y, Stucka S, Zhang J, Chandonnet H, Lippa B, Ryan MD, Baber JC. Zhang X, et al. Among authors: zhang j. J Comput Aided Mol Des. 2018 Apr;32(4):573-582. doi: 10.1007/s10822-018-0113-2. Epub 2018 Mar 26. J Comput Aided Mol Des. 2018. PMID: 29582229
The design and discovery of water soluble 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as multitargeted receptor tyrosine kinase inhibitors and microtubule targeting antitumor agents.
Zhang X, Raghavan S, Ihnat M, Thorpe JE, Disch BC, Bastian A, Bailey-Downs LC, Dybdal-Hargreaves NF, Rohena CC, Hamel E, Mooberry SL, Gangjee A. Zhang X, et al. Bioorg Med Chem. 2014 Jul 15;22(14):3753-72. doi: 10.1016/j.bmc.2014.04.049. Epub 2014 May 14. Bioorg Med Chem. 2014. PMID: 24890652 Free PMC article.
The design, synthesis and biological evaluation of conformationally restricted 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as multi-targeted receptor tyrosine kinase and microtubule inhibitors as potential antitumor agents.
Zhang X, Raghavan S, Ihnat M, Hamel E, Zammiello C, Bastian A, Mooberry SL, Gangjee A. Zhang X, et al. Bioorg Med Chem. 2015 May 15;23(10):2408-23. doi: 10.1016/j.bmc.2015.03.061. Epub 2015 Mar 30. Bioorg Med Chem. 2015. PMID: 25882519 Free PMC article.
183,002 results
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