Manning BD - Search Results

1

Advances and Future Directions for Tuberous Sclerosis Complex Research: Recommendations From the 2015 Strategic Planning Conference.

Sahin M, Henske EP, Manning BD, Ess KC, Bissler JJ, Klann E, Kwiatkowski DJ, Roberds SL, Silva AJ, Hillaire-Clarke CS, Young LR, Zervas M, Mamounas LA; Tuberous Sclerosis Complex Working Group to Update the Research Plan. Sahin M, et al. Among authors: manning bd. Pediatr Neurol. 2016 Jul;60:1-12. doi: 10.1016/j.pediatrneurol.2016.03.015. Epub 2016 Apr 2. Pediatr Neurol. 2016. PMID: 27267556 Free PMC article.

2

Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling.

Tee AR, Fingar DC, Manning BD, Kwiatkowski DJ, Cantley LC, Blenis J. Tee AR, et al. Among authors: manning bd. Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13571-6. doi: 10.1073/pnas.202476899. Epub 2002 Sep 23. Proc Natl Acad Sci U S A. 2002. PMID: 12271141 Free PMC article.

3

Feedback inhibition of Akt signaling limits the growth of tumors lacking Tsc2.

Manning BD, Logsdon MN, Lipovsky AI, Abbott D, Kwiatkowski DJ, Cantley LC. Manning BD, et al. Genes Dev. 2005 Aug 1;19(15):1773-8. doi: 10.1101/gad.1314605. Epub 2005 Jul 18. Genes Dev. 2005. PMID: 16027169 Free PMC article.

4

Tuberous sclerosis: a GAP at the crossroads of multiple signaling pathways.

Kwiatkowski DJ, Manning BD. Kwiatkowski DJ, et al. Among authors: manning bd. Hum Mol Genet. 2005 Oct 15;14 Spec No. 2:R251-8. doi: 10.1093/hmg/ddi260. Hum Mol Genet. 2005. PMID: 16244323 Review.

5

S6K1 regulates GSK3 under conditions of mTOR-dependent feedback inhibition of Akt.

Zhang HH, Lipovsky AI, Dibble CC, Sahin M, Manning BD. Zhang HH, et al. Among authors: manning bd. Mol Cell. 2006 Oct 20;24(2):185-97. doi: 10.1016/j.molcel.2006.09.019. Mol Cell. 2006. PMID: 17052453 Free PMC article.

6

Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosis.

Ozcan U, Ozcan L, Yilmaz E, Düvel K, Sahin M, Manning BD, Hotamisligil GS. Ozcan U, et al. Among authors: manning bd. Mol Cell. 2008 Mar 14;29(5):541-51. doi: 10.1016/j.molcel.2007.12.023. Mol Cell. 2008. PMID: 18342602 Free PMC article.

7

Akt stimulates hepatic SREBP1c and lipogenesis through parallel mTORC1-dependent and independent pathways.

Yecies JL, Zhang HH, Menon S, Liu S, Yecies D, Lipovsky AI, Gorgun C, Kwiatkowski DJ, Hotamisligil GS, Lee CH, Manning BD. Yecies JL, et al. Among authors: manning bd. Cell Metab. 2011 Jul 6;14(1):21-32. doi: 10.1016/j.cmet.2011.06.002. Cell Metab. 2011. PMID: 21723501 Free PMC article.

8

Therapeutic trial of metformin and bortezomib in a mouse model of tuberous sclerosis complex (TSC).

Auricchio N, Malinowska I, Shaw R, Manning BD, Kwiatkowski DJ. Auricchio N, et al. Among authors: manning bd. PLoS One. 2012;7(2):e31900. doi: 10.1371/journal.pone.0031900. Epub 2012 Feb 21. PLoS One. 2012. PMID: 22363765 Free PMC article.

9

Chronic activation of mTOR complex 1 is sufficient to cause hepatocellular carcinoma in mice.

Menon S, Yecies JL, Zhang HH, Howell JJ, Nicholatos J, Harputlugil E, Bronson RT, Kwiatkowski DJ, Manning BD. Menon S, et al. Among authors: manning bd. Sci Signal. 2012 Mar 27;5(217):ra24. doi: 10.1126/scisignal.2002739. Sci Signal. 2012. PMID: 22457330 Free PMC article.

10

TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1.

Dibble CC, Elis W, Menon S, Qin W, Klekota J, Asara JM, Finan PM, Kwiatkowski DJ, Murphy LO, Manning BD. Dibble CC, et al. Among authors: manning bd. Mol Cell. 2012 Aug 24;47(4):535-46. doi: 10.1016/j.molcel.2012.06.009. Epub 2012 Jul 12. Mol Cell. 2012. PMID: 22795129 Free PMC article.

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