Joerger AC - Search Results

1

Harnessing Fluorine-Sulfur Contacts and Multipolar Interactions for the Design of p53 Mutant Y220C Rescue Drugs.

Bauer MR, Jones RN, Baud MG, Wilcken R, Boeckler FM, Fersht AR, Joerger AC, Spencer J. Bauer MR, et al. Among authors: joerger ac. ACS Chem Biol. 2016 Aug 19;11(8):2265-74. doi: 10.1021/acschembio.6b00315. Epub 2016 Jun 21. ACS Chem Biol. 2016. PMID: 27267810 Free PMC article.

2

Mimicking natural evolution in vitro: an N-acetylneuraminate lyase mutant with an increased dihydrodipicolinate synthase activity.

Joerger AC, Mayer S, Fersht AR. Joerger AC, et al. Proc Natl Acad Sci U S A. 2003 May 13;100(10):5694-9. doi: 10.1073/pnas.0531477100. Epub 2003 Apr 23. Proc Natl Acad Sci U S A. 2003. PMID: 12711733 Free PMC article.

3

Crystal structure of a superstable mutant of human p53 core domain. Insights into the mechanism of rescuing oncogenic mutations.

Joerger AC, Allen MD, Fersht AR. Joerger AC, et al. J Biol Chem. 2004 Jan 9;279(2):1291-6. doi: 10.1074/jbc.M309732200. Epub 2003 Oct 8. J Biol Chem. 2004. PMID: 14534297 Free article.

4

Structures of p53 cancer mutants and mechanism of rescue by second-site suppressor mutations.

Joerger AC, Ang HC, Veprintsev DB, Blair CM, Fersht AR. Joerger AC, et al. J Biol Chem. 2005 Apr 22;280(16):16030-7. doi: 10.1074/jbc.M500179200. Epub 2005 Feb 9. J Biol Chem. 2005. PMID: 15703170 Free article.

5

Effects of common cancer mutations on stability and DNA binding of full-length p53 compared with isolated core domains.

Ang HC, Joerger AC, Mayer S, Fersht AR. Ang HC, et al. Among authors: joerger ac. J Biol Chem. 2006 Aug 4;281(31):21934-21941. doi: 10.1074/jbc.M604209200. Epub 2006 Jun 5. J Biol Chem. 2006. PMID: 16754663 Free article.

6

Structural basis for understanding oncogenic p53 mutations and designing rescue drugs.

Joerger AC, Ang HC, Fersht AR. Joerger AC, et al. Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15056-61. doi: 10.1073/pnas.0607286103. Epub 2006 Oct 2. Proc Natl Acad Sci U S A. 2006. PMID: 17015838 Free PMC article.

7

Structure-function-rescue: the diverse nature of common p53 cancer mutants.

Joerger AC, Fersht AR. Joerger AC, et al. Oncogene. 2007 Apr 2;26(15):2226-42. doi: 10.1038/sj.onc.1210291. Oncogene. 2007. PMID: 17401432 Review.

8

Structural biology of the tumor suppressor p53 and cancer-associated mutants.

Joerger AC, Fersht AR. Joerger AC, et al. Adv Cancer Res. 2007;97:1-23. doi: 10.1016/S0065-230X(06)97001-8. Adv Cancer Res. 2007. PMID: 17419939 Review.

9

Correlation of levels of folded recombinant p53 in escherichia coli with thermodynamic stability in vitro.

Mayer S, Rüdiger S, Ang HC, Joerger AC, Fersht AR. Mayer S, et al. Among authors: joerger ac. J Mol Biol. 2007 Sep 7;372(1):268-76. doi: 10.1016/j.jmb.2007.06.044. Epub 2007 Jun 22. J Mol Biol. 2007. PMID: 17631895

10

Structural biology of the tumor suppressor p53.

Joerger AC, Fersht AR. Joerger AC, et al. Annu Rev Biochem. 2008;77:557-82. doi: 10.1146/annurev.biochem.77.060806.091238. Annu Rev Biochem. 2008. PMID: 18410249 Review.

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