Gadkar K - Search Results

1

A Six-Stage Workflow for Robust Application of Systems Pharmacology.

Gadkar K, Kirouac DC, Mager DE, van der Graaf PH, Ramanujan S. Gadkar K, et al. CPT Pharmacometrics Syst Pharmacol. 2016 May;5(5):235-49. doi: 10.1002/psp4.12071. Epub 2016 Apr 16. CPT Pharmacometrics Syst Pharmacol. 2016. PMID: 27299936 Free PMC article.

2

Mechanisms mediating anti-CD3 antibody efficacy: insights from a mathematical model of type 1 diabetes.

Young DL, Ramanujan S, Kreuwel HT, Whiting CC, Gadkar KG, Shoda LK. Young DL, et al. Among authors: gadkar kg. Ann N Y Acad Sci. 2006 Oct;1079:369-73. doi: 10.1196/annals.1375.057. Ann N Y Acad Sci. 2006. PMID: 17130581

3

A Mechanistic Systems Pharmacology Model for Prediction of LDL Cholesterol Lowering by PCSK9 Antagonism in Human Dyslipidemic Populations.

Gadkar K, Budha N, Baruch A, Davis JD, Fielder P, Ramanujan S. Gadkar K, et al. CPT Pharmacometrics Syst Pharmacol. 2014 Nov 26;3(11):e149. doi: 10.1038/psp.2014.47. CPT Pharmacometrics Syst Pharmacol. 2014. PMID: 25426564 Free PMC article.

4

Mechanism-Based Pharmacokinetic/Pharmacodynamic Model for THIOMAB™ Drug Conjugates.

Sukumaran S, Gadkar K, Zhang C, Bhakta S, Liu L, Xu K, Raab H, Yu SF, Mai E, Fourie-O'Donohue A, Kozak KR, Ramanujan S, Junutula JR, Lin K. Sukumaran S, et al. Among authors: gadkar k. Pharm Res. 2015 Jun;32(6):1884-93. doi: 10.1007/s11095-014-1582-1. Epub 2014 Dec 2. Pharm Res. 2015. PMID: 25446772

5

Evaluation of HDL-modulating interventions for cardiovascular risk reduction using a systems pharmacology approach.

Gadkar K, Lu J, Sahasranaman S, Davis J, Mazer NA, Ramanujan S. Gadkar K, et al. J Lipid Res. 2016 Jan;57(1):46-55. doi: 10.1194/jlr.M057943. Epub 2015 Nov 1. J Lipid Res. 2016. PMID: 26522778 Free PMC article.

6

Mathematical PKPD and safety model of bispecific TfR/BACE1 antibodies for the optimization of antibody uptake in brain.

Gadkar K, Yadav DB, Zuchero JY, Couch JA, Kanodia J, Kenrick MK, Atwal JK, Dennis MS, Prabhu S, Watts RJ, Joseph SB, Ramanujan S. Gadkar K, et al. Eur J Pharm Biopharm. 2016 Apr;101:53-61. doi: 10.1016/j.ejpb.2016.01.009. Epub 2016 Jan 25. Eur J Pharm Biopharm. 2016. PMID: 26820920

7

Prospective Design of Anti-Transferrin Receptor Bispecific Antibodies for Optimal Delivery into the Human Brain.

Kanodia JS, Gadkar K, Bumbaca D, Zhang Y, Tong RK, Luk W, Hoyte K, Lu Y, Wildsmith KR, Couch JA, Watts RJ, Dennis MS, Ernst JA, Scearce-Levie K, Atwal JK, Ramanujan S, Joseph S. Kanodia JS, et al. Among authors: gadkar k. CPT Pharmacometrics Syst Pharmacol. 2016 May;5(5):283-91. doi: 10.1002/psp4.12081. Epub 2016 May 17. CPT Pharmacometrics Syst Pharmacol. 2016. PMID: 27299941 Free PMC article.

8

Development and Translational Application of an Integrated, Mechanistic Model of Antibody-Drug Conjugate Pharmacokinetics.

Sukumaran S, Zhang C, Leipold DD, Saad OM, Xu K, Gadkar K, Samineni D, Wang B, Milojic-Blair M, Carrasco-Triguero M, Rubinfeld B, Fielder P, Lin K, Ramanujan S. Sukumaran S, et al. Among authors: gadkar k. AAPS J. 2017 Jan;19(1):130-140. doi: 10.1208/s12248-016-9993-z. Epub 2016 Sep 27. AAPS J. 2017. PMID: 27679517

9

Quantitative systems pharmacology: a promising approach for translational pharmacology.

Gadkar K, Kirouac D, Parrott N, Ramanujan S. Gadkar K, et al. Drug Discov Today Technol. 2016 Sep-Dec;21-22:57-65. doi: 10.1016/j.ddtec.2016.11.001. Epub 2016 Nov 24. Drug Discov Today Technol. 2016. PMID: 27978989 Review.

10

Methodologies for Quantitative Systems Pharmacology (QSP) Models: Design and Estimation.

Ribba B, Grimm HP, Agoram B, Davies MR, Gadkar K, Niederer S, van Riel N, Timmis J, van der Graaf PH. Ribba B, et al. Among authors: gadkar k. CPT Pharmacometrics Syst Pharmacol. 2017 Aug;6(8):496-498. doi: 10.1002/psp4.12206. Epub 2017 Jul 11. CPT Pharmacometrics Syst Pharmacol. 2017. PMID: 28585415 Free PMC article.

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