Schofield CJ - Search Results

1

The road to avibactam: the first clinically useful non-β-lactam working somewhat like a β-lactam.

Wang DY, Abboud MI, Markoulides MS, Brem J, Schofield CJ. Wang DY, et al. Among authors: schofield cj. Future Med Chem. 2016 Jun;8(10):1063-84. doi: 10.4155/fmc-2016-0078. Epub 2016 Jun 21. Future Med Chem. 2016. PMID: 27327972 Review.

2

Inhibitors of the FEZ-1 metallo-beta-lactamase.

Liénard BM, Horsfall LE, Galleni M, Frère JM, Schofield CJ. Liénard BM, et al. Among authors: schofield cj. Bioorg Med Chem Lett. 2007 Feb 15;17(4):964-8. doi: 10.1016/j.bmcl.2006.11.053. Epub 2006 Nov 18. Bioorg Med Chem Lett. 2007. PMID: 17157014

3

Dynamic combinatorial mass spectrometry leads to metallo-beta-lactamase inhibitors.

Liénard BM, Hüting R, Lassaux P, Galleni M, Frère JM, Schofield CJ. Liénard BM, et al. Among authors: schofield cj. J Med Chem. 2008 Feb 14;51(3):684-8. doi: 10.1021/jm070866g. Epub 2008 Jan 19. J Med Chem. 2008. PMID: 18205296

4

Structural basis for the broad-spectrum inhibition of metallo-beta-lactamases by thiols.

Liénard BM, Garau G, Horsfall L, Karsisiotis AI, Damblon C, Lassaux P, Papamicael C, Roberts GC, Galleni M, Dideberg O, Frère JM, Schofield CJ. Liénard BM, et al. Among authors: schofield cj. Org Biomol Chem. 2008 Jul 7;6(13):2282-94. doi: 10.1039/b802311e. Epub 2008 May 7. Org Biomol Chem. 2008. PMID: 18563261

5

Synthesis and evaluation of 3-(dihydroxyboryl)benzoic acids as D,D-carboxypeptidase R39 inhibitors.

Inglis SR, Zervosen A, Woon EC, Gerards T, Teller N, Fischer DS, Luxen A, Schofield CJ. Inglis SR, et al. Among authors: schofield cj. J Med Chem. 2009 Oct 8;52(19):6097-106. doi: 10.1021/jm9009718. J Med Chem. 2009. PMID: 19731939

6

Structural basis for the interaction of lactivicins with serine beta-lactamases.

Brown T Jr, Charlier P, Herman R, Schofield CJ, Sauvage E. Brown T Jr, et al. Among authors: schofield cj. J Med Chem. 2010 Aug 12;53(15):5890-4. doi: 10.1021/jm100437u. J Med Chem. 2010. PMID: 20593835 Free article.

7

Dynamic combinatorial mass spectrometry leads to inhibitors of a 2-oxoglutarate-dependent nucleic acid demethylase.

Woon EC, Demetriades M, Bagg EA, Aik W, Krylova SM, Ma JH, Chan M, Walport LJ, Wegman DW, Dack KN, McDonough MA, Krylov SN, Schofield CJ. Woon EC, et al. Among authors: schofield cj. J Med Chem. 2012 Mar 8;55(5):2173-84. doi: 10.1021/jm201417e. Epub 2012 Feb 22. J Med Chem. 2012. PMID: 22263962

8

Progress in the development and application of small molecule inhibitors of bromodomain-acetyl-lysine interactions.

Hewings DS, Rooney TP, Jennings LE, Hay DA, Schofield CJ, Brennan PE, Knapp S, Conway SJ. Hewings DS, et al. Among authors: schofield cj. J Med Chem. 2012 Nov 26;55(22):9393-413. doi: 10.1021/jm300915b. Epub 2012 Sep 27. J Med Chem. 2012. PMID: 22924434 Review.

9

The enzymes of β-lactam biosynthesis.

Hamed RB, Gomez-Castellanos JR, Henry L, Ducho C, McDonough MA, Schofield CJ. Hamed RB, et al. Among authors: schofield cj. Nat Prod Rep. 2013 Jan;30(1):21-107. doi: 10.1039/c2np20065a. Nat Prod Rep. 2013. PMID: 23135477 Review.

10

Reporter ligand NMR screening method for 2-oxoglutarate oxygenase inhibitors.

Leung IK, Demetriades M, Hardy AP, Lejeune C, Smart TJ, Szöllössi A, Kawamura A, Schofield CJ, Claridge TD. Leung IK, et al. Among authors: schofield cj. J Med Chem. 2013 Jan 24;56(2):547-55. doi: 10.1021/jm301583m. Epub 2013 Jan 4. J Med Chem. 2013. PMID: 23234607 Free PMC article.

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