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IL-18 attenuates experimental choroidal neovascularization as a potential therapy for wet age-related macular degeneration.
Doyle SL, Ozaki E, Brennan K, Humphries MM, Mulfaul K, Keaney J, Kenna PF, Maminishkis A, Kiang AS, Saunders SP, Hams E, Lavelle EC, Gardiner C, Fallon PG, Adamson P, Humphries P, Campbell M. Doyle SL, et al. Among authors: brennan k. Sci Transl Med. 2014 Apr 2;6(230):230ra44. doi: 10.1126/scitranslmed.3007616. Sci Transl Med. 2014. PMID: 24695684
Low Density Granulocytes in ANCA Vasculitis Are Heterogenous and Hypo-Responsive to Anti-Myeloperoxidase Antibodies.
Ui Mhaonaigh A, Coughlan AM, Dwivedi A, Hartnett J, Cabral J, Moran B, Brennan K, Doyle SL, Hughes K, Lucey R, Floudas A, Fearon U, McGrath S, Cormican S, De Bhailis A, Molloy EJ, Brady G, Little MA. Ui Mhaonaigh A, et al. Among authors: brennan k. Front Immunol. 2019 Nov 7;10:2603. doi: 10.3389/fimmu.2019.02603. eCollection 2019. Front Immunol. 2019. PMID: 31781107 Free PMC article.
Poxviral protein A52 stimulates p38 mitogen-activated protein kinase (MAPK) activation by causing tumor necrosis factor receptor-associated factor 6 (TRAF6) self-association leading to transforming growth factor β-activated kinase 1 (TAK1) recruitment.
Stack J, Hurst TP, Flannery SM, Brennan K, Rupp S, Oda SI, Khan AR, Bowie AG. Stack J, et al. Among authors: brennan k. J Biol Chem. 2013 Nov 22;288(47):33642-33653. doi: 10.1074/jbc.M113.485490. Epub 2013 Oct 10. J Biol Chem. 2013. PMID: 24114841 Free PMC article.
Type 1 IFN Induction by Cytosolic Nucleic Acid Is Intact in Neonatal Mononuclear Cells, Contrasting Starkly with Neonatal Hyporesponsiveness to TLR Ligation Due to Independence from Endosome-Mediated IRF3 Activation.
Brennan K, O'Leary BD, Mc Laughlin D, Breen EP, Connolly E, Ali N, O'Driscoll DN, Ozaki E, Mahony R, Mulfaul K, Ryan AM, Ni Chianain A, McHugh A, Molloy EJ, Hogan AE, Paran S, McAuliffe FM, Doyle SL. Brennan K, et al. J Immunol. 2018 Aug 15;201(4):1131-1143. doi: 10.4049/jimmunol.1700956. Epub 2018 Jul 6. J Immunol. 2018. PMID: 29980613
614 results