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PIK3CA mutant tumors depend on oxoglutarate dehydrogenase.
Ilic N, Birsoy K, Aguirre AJ, Kory N, Pacold ME, Singh S, Moody SE, DeAngelo JD, Spardy NA, Freinkman E, Weir BA, Tsherniak A, Cowley GS, Root DE, Asara JM, Vazquez F, Widlund HR, Sabatini DM, Hahn WC. Ilic N, et al. Among authors: freinkman e. Proc Natl Acad Sci U S A. 2017 Apr 25;114(17):E3434-E3443. doi: 10.1073/pnas.1617922114. Epub 2017 Apr 10. Proc Natl Acad Sci U S A. 2017. PMID: 28396387 Free PMC article.
Ablation of insulin receptor substrates 1 and 2 suppresses Kras-driven lung tumorigenesis.
Xu H, Lee MS, Tsai PY, Adler AS, Curry NL, Challa S, Freinkman E, Hitchcock DS, Copps KD, White MF, Bronson RT, Marcotrigiano M, Wu Y, Clish CB, Kalaany NY. Xu H, et al. Among authors: freinkman e. Proc Natl Acad Sci U S A. 2018 Apr 17;115(16):4228-4233. doi: 10.1073/pnas.1718414115. Epub 2018 Apr 2. Proc Natl Acad Sci U S A. 2018. PMID: 29610318 Free PMC article.
47 results