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Glutathione S-Transferase P1 Protects Against Amodiaquine Quinoneimines-Induced Cytotoxicity but Does Not Prevent Activation of Endoplasmic Reticulum Stress in HepG2 Cells.
Zhang Y, den Braver-Sewradj SP, den Braver MW, Hiemstra S, Vermeulen NPE, van de Water B, Commandeur JNM, Vos JC. Zhang Y, et al. Among authors: hiemstra s. Front Pharmacol. 2018 Apr 18;9:388. doi: 10.3389/fphar.2018.00388. eCollection 2018. Front Pharmacol. 2018. PMID: 29720942 Free PMC article.
High-throughput confocal imaging of differentiated 3D liver-like spheroid cellular stress response reporters for identification of drug-induced liver injury liability.
Hiemstra S, Ramaiahgari SC, Wink S, Callegaro G, Coonen M, Meerman J, Jennen D, van den Nieuwendijk K, Dankers A, Snoeys J, de Bont H, Price L, van de Water B. Hiemstra S, et al. Arch Toxicol. 2019 Oct;93(10):2895-2911. doi: 10.1007/s00204-019-02552-0. Epub 2019 Aug 27. Arch Toxicol. 2019. PMID: 31552476
Mining a human transcriptome database for chemical modulators of NRF2.
Rooney JP, Chorley B, Hiemstra S, Wink S, Wang X, Bell DA, van de Water B, Corton JC. Rooney JP, et al. Among authors: hiemstra s. PLoS One. 2020 Sep 28;15(9):e0239367. doi: 10.1371/journal.pone.0239367. eCollection 2020. PLoS One. 2020. PMID: 32986742 Free PMC article.
Mapping the dynamics of Nrf2 antioxidant and NFκB inflammatory responses by soft electrophilic chemicals in human liver cells defines the transition from adaptive to adverse responses.
Ter Braak B, Klip JE, Wink S, Hiemstra S, Cooper SL, Middleton A, White A, van de Water B. Ter Braak B, et al. Among authors: hiemstra s. Toxicol In Vitro. 2022 Oct;84:105419. doi: 10.1016/j.tiv.2022.105419. Epub 2022 Jun 17. Toxicol In Vitro. 2022. PMID: 35724838 Free article.
Collaborative SAR Modeling and Prospective In Vitro Validation of Oxidative Stress Activation in Human HepG2 Cells.
Béquignon OJM, Gómez-Tamayo JC, Lenselink EB, Wink S, Hiemstra S, Lam CC, Gadaleta D, Roncaglioni A, Norinder U, Water BV, Pastor M, van Westen GJP. Béquignon OJM, et al. Among authors: hiemstra s. J Chem Inf Model. 2023 Sep 11;63(17):5433-5445. doi: 10.1021/acs.jcim.3c00220. Epub 2023 Aug 24. J Chem Inf Model. 2023. PMID: 37616385 Free PMC article.
62 results