Gibbons RJ - Search Results

1

Genetic dissection of the α-globin super-enhancer in vivo.

Hay D, Hughes JR, Babbs C, Davies JOJ, Graham BJ, Hanssen L, Kassouf MT, Marieke Oudelaar AM, Sharpe JA, Suciu MC, Telenius J, Williams R, Rode C, Li PS, Pennacchio LA, Sloane-Stanley JA, Ayyub H, Butler S, Sauka-Spengler T, Gibbons RJ, Smith AJH, Wood WG, Higgs DR. Hay D, et al. Among authors: gibbons rj. Nat Genet. 2016 Aug;48(8):895-903. doi: 10.1038/ng.3605. Epub 2016 Jul 4. Nat Genet. 2016. PMID: 27376235 Free PMC article.

2

Using genomics to study how chromatin influences gene expression.

Higgs DR, Vernimmen D, Hughes J, Gibbons R. Higgs DR, et al. Annu Rev Genomics Hum Genet. 2007;8:299-325. doi: 10.1146/annurev.genom.8.080706.092323. Annu Rev Genomics Hum Genet. 2007. PMID: 17506662 Review.

3

Analysis of hundreds of cis-regulatory landscapes at high resolution in a single, high-throughput experiment.

Hughes JR, Roberts N, McGowan S, Hay D, Giannoulatou E, Lynch M, De Gobbi M, Taylor S, Gibbons R, Higgs DR. Hughes JR, et al. Nat Genet. 2014 Feb;46(2):205-12. doi: 10.1038/ng.2871. Epub 2014 Jan 12. Nat Genet. 2014. PMID: 24413732 Free article.

4

Identification of acquired somatic mutations in the gene encoding chromatin-remodeling factor ATRX in the alpha-thalassemia myelodysplasia syndrome (ATMDS).

Gibbons RJ, Pellagatti A, Garrick D, Wood WG, Malik N, Ayyub H, Langford C, Boultwood J, Wainscoat JS, Higgs DR. Gibbons RJ, et al. Nat Genet. 2003 Aug;34(4):446-9. doi: 10.1038/ng1213. Nat Genet. 2003. PMID: 12858175

5

Tissue-specific histone modification and transcription factor binding in alpha globin gene expression.

De Gobbi M, Anguita E, Hughes J, Sloane-Stanley JA, Sharpe JA, Koch CM, Dunham I, Gibbons RJ, Wood WG, Higgs DR. De Gobbi M, et al. Among authors: gibbons rj. Blood. 2007 Dec 15;110(13):4503-10. doi: 10.1182/blood-2007-06-097964. Epub 2007 Aug 22. Blood. 2007. PMID: 17715390 Free article.

6

Understanding α-globin gene regulation and implications for the treatment of β-thalassemia.

Mettananda S, Gibbons RJ, Higgs DR. Mettananda S, et al. Among authors: gibbons rj. Ann N Y Acad Sci. 2016 Mar;1368(1):16-24. doi: 10.1111/nyas.12988. Epub 2015 Dec 22. Ann N Y Acad Sci. 2016. PMID: 26695885 Review.

7

Editing an α-globin enhancer in primary human hematopoietic stem cells as a treatment for β-thalassemia.

Mettananda S, Fisher CA, Hay D, Badat M, Quek L, Clark K, Hublitz P, Downes D, Kerry J, Gosden M, Telenius J, Sloane-Stanley JA, Faustino P, Coelho A, Doondeea J, Usukhbayar B, Sopp P, Sharpe JA, Hughes JR, Vyas P, Gibbons RJ, Higgs DR. Mettananda S, et al. Among authors: gibbons rj. Nat Commun. 2017 Sep 4;8(1):424. doi: 10.1038/s41467-017-00479-7. Nat Commun. 2017. PMID: 28871148 Free PMC article.

8

A gain-of-function single nucleotide variant creates a new promoter which acts as an orientation-dependent enhancer-blocker.

Bozhilov YK, Downes DJ, Telenius J, Marieke Oudelaar A, Olivier EN, Mountford JC, Hughes JR, Gibbons RJ, Higgs DR. Bozhilov YK, et al. Among authors: gibbons rj. Nat Commun. 2021 Jun 21;12(1):3806. doi: 10.1038/s41467-021-23980-6. Nat Commun. 2021. PMID: 34155213 Free PMC article.

9

Syndromal mental retardation due to mutations in a regulator of gene expression.

Gibbons RJ, Picketts DJ, Higgs DR. Gibbons RJ, et al. Hum Mol Genet. 1995;4 Spec No:1705-9. doi: 10.1093/hmg/4.suppl_1.1705. Hum Mol Genet. 1995. PMID: 8541868 Review.

10

The alpha-thalassemia/mental retardation syndromes.

Gibbons RJ, Higgs DR. Gibbons RJ, et al. Medicine (Baltimore). 1996 Mar;75(2):45-52. doi: 10.1097/00005792-199603000-00001. Medicine (Baltimore). 1996. PMID: 8606626 Free article. Review.

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