Wu H - Search Results

1

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores.

Liu X, Zhang Z, Ruan J, Pan Y, Magupalli VG, Wu H, Lieberman J. Liu X, et al. Among authors: wu h. Nature. 2016 Jul 7;535(7610):153-8. doi: 10.1038/nature18629. Nature. 2016. PMID: 27383986 Free PMC article.

2

Crystal structure of the F27G AIM2 PYD mutant and similarities of its self-association to DED/DED interactions.

Lu A, Kabaleeswaran V, Fu T, Magupalli VG, Wu H. Lu A, et al. Among authors: wu h. J Mol Biol. 2014 Apr 3;426(7):1420-7. doi: 10.1016/j.jmb.2013.12.029. Epub 2014 Jan 7. J Mol Biol. 2014. PMID: 24406744 Free PMC article.

3

Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes.

Lu A, Magupalli VG, Ruan J, Yin Q, Atianand MK, Vos MR, Schröder GF, Fitzgerald KA, Wu H, Egelman EH. Lu A, et al. Among authors: wu h. Cell. 2014 Mar 13;156(6):1193-1206. doi: 10.1016/j.cell.2014.02.008. Cell. 2014. PMID: 24630722 Free PMC article.

4

Structural mechanisms of inflammasome assembly.

Lu A, Wu H. Lu A, et al. Among authors: wu h. FEBS J. 2015 Feb;282(3):435-44. doi: 10.1111/febs.13133. Epub 2014 Nov 21. FEBS J. 2015. PMID: 25354325 Free PMC article. Review.

5

SMOCs: supramolecular organizing centres that control innate immunity.

Kagan JC, Magupalli VG, Wu H. Kagan JC, et al. Among authors: wu h. Nat Rev Immunol. 2014 Dec;14(12):821-6. doi: 10.1038/nri3757. Epub 2014 Oct 31. Nat Rev Immunol. 2014. PMID: 25359439 Free PMC article. Review.

6

Active Pin1 is a key target of all-trans retinoic acid in acute promyelocytic leukemia and breast cancer.

Wei S, Kozono S, Kats L, Nechama M, Li W, Guarnerio J, Luo M, You MH, Yao Y, Kondo A, Hu H, Bozkurt G, Moerke NJ, Cao S, Reschke M, Chen CH, Rego EM, Lo-Coco F, Cantley LC, Lee TH, Wu H, Zhang Y, Pandolfi PP, Zhou XZ, Lu KP. Wei S, et al. Among authors: wu h. Nat Med. 2015 May;21(5):457-66. doi: 10.1038/nm.3839. Epub 2015 Apr 13. Nat Med. 2015. PMID: 25849135 Free PMC article.

7

The ubiquitin-modifying enzyme A20 restricts ubiquitination of the kinase RIPK3 and protects cells from necroptosis.

Onizawa M, Oshima S, Schulze-Topphoff U, Oses-Prieto JA, Lu T, Tavares R, Prodhomme T, Duong B, Whang MI, Advincula R, Agelidis A, Barrera J, Wu H, Burlingame A, Malynn BA, Zamvil SS, Ma A. Onizawa M, et al. Among authors: wu h. Nat Immunol. 2015 Jun;16(6):618-27. doi: 10.1038/ni.3172. Epub 2015 May 4. Nat Immunol. 2015. PMID: 25939025 Free PMC article.

8

Cryo-EM structure of the activated NAIP2-NLRC4 inflammasome reveals nucleated polymerization.

Zhang L, Chen S, Ruan J, Wu J, Tong AB, Yin Q, Li Y, David L, Lu A, Wang WL, Marks C, Ouyang Q, Zhang X, Mao Y, Wu H. Zhang L, et al. Among authors: wu h, wu j. Science. 2015 Oct 23;350(6259):404-9. doi: 10.1126/science.aac5789. Epub 2015 Oct 8. Science. 2015. PMID: 26449474 Free PMC article.

9

Plasticity in PYD assembly revealed by cryo-EM structure of the PYD filament of AIM2.

Lu A, Li Y, Yin Q, Ruan J, Yu X, Egelman E, Wu H. Lu A, et al. Among authors: wu h. Cell Discov. 2015;1:15013-. doi: 10.1038/celldisc.2015.13. Epub 2015 Jun 23. Cell Discov. 2015. PMID: 26583071 Free PMC article.

10

Molecular basis of caspase-1 polymerization and its inhibition by a new capping mechanism.

Lu A, Li Y, Schmidt FI, Yin Q, Chen S, Fu TM, Tong AB, Ploegh HL, Mao Y, Wu H. Lu A, et al. Among authors: wu h. Nat Struct Mol Biol. 2016 May;23(5):416-25. doi: 10.1038/nsmb.3199. Epub 2016 Apr 4. Nat Struct Mol Biol. 2016. PMID: 27043298 Free PMC article.

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