Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

20 results

Filters applied: . Clear all
Results are displayed in a computed author sort order. The Publication Date timeline is not available.
Page 1
Design and synthesis of aminothiazole modulators of the gamma-secretase enzyme.
Rynearson KD, Buckle RN, Barnes KD, Herr RJ, Mayhew NJ, Paquette WD, Sakwa SA, Nguyen PD, Johnson G, Tanzi RE, Wagner SL. Rynearson KD, et al. Bioorg Med Chem Lett. 2016 Aug 15;26(16):3928-37. doi: 10.1016/j.bmcl.2016.07.011. Epub 2016 Jul 6. Bioorg Med Chem Lett. 2016. PMID: 27426299
Soluble γ-secretase modulators selectively inhibit the production of the 42-amino acid amyloid β peptide variant and augment the production of multiple carboxy-truncated amyloid β species.
Wagner SL, Zhang C, Cheng S, Nguyen P, Zhang X, Rynearson KD, Wang R, Li Y, Sisodia SS, Mobley WC, Tanzi RE. Wagner SL, et al. Among authors: rynearson kd. Biochemistry. 2014 Feb 4;53(4):702-13. doi: 10.1021/bi401537v. Epub 2014 Jan 22. Biochemistry. 2014. PMID: 24401146 Free PMC article.
Pharmacological and Toxicological Properties of the Potent Oral γ-Secretase Modulator BPN-15606.
Wagner SL, Rynearson KD, Duddy SK, Zhang C, Nguyen PD, Becker A, Vo U, Masliah D, Monte L, Klee JB, Echmalian CM, Xia W, Quinti L, Johnson G, Lin JH, Kim DY, Mobley WC, Rissman RA, Tanzi RE. Wagner SL, et al. Among authors: rynearson kd. J Pharmacol Exp Ther. 2017 Jul;362(1):31-44. doi: 10.1124/jpet.117.240861. Epub 2017 Apr 17. J Pharmacol Exp Ther. 2017. PMID: 28416568 Free PMC article.
Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-β in iPSC-Derived Alzheimer's Disease Neurons.
van der Kant R, Langness VF, Herrera CM, Williams DA, Fong LK, Leestemaker Y, Steenvoorden E, Rynearson KD, Brouwers JF, Helms JB, Ovaa H, Giera M, Wagner SL, Bang AG, Goldstein LSB. van der Kant R, et al. Among authors: rynearson kd. Cell Stem Cell. 2019 Mar 7;24(3):363-375.e9. doi: 10.1016/j.stem.2018.12.013. Epub 2019 Jan 24. Cell Stem Cell. 2019. PMID: 30686764 Free PMC article.
20 results