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Identification of selective inhibitors of RET and comparison with current clinical candidates through development and validation of a robust screening cascade.
Watson AJ, Hopkins GV, Hitchin S, Begum H, Jones S, Jordan A, Holt S, March HN, Newton R, Small H, Stowell A, Waddell ID, Waszkowycz B, Ogilvie DJ. Watson AJ, et al. Among authors: holt s. F1000Res. 2016 May 26;5:1005. doi: 10.12688/f1000research.8724.2. eCollection 2016. F1000Res. 2016. PMID: 27429741 Free PMC article.
The discovery of 2-substituted phenol quinazolines as potent RET kinase inhibitors with improved KDR selectivity.
Newton R, Bowler KA, Burns EM, Chapman PJ, Fairweather EE, Fritzl SJR, Goldberg KM, Hamilton NM, Holt SV, Hopkins GV, Jones SD, Jordan AM, Lyons AJ, Nikki March H, McDonald NQ, Maguire LA, Mould DP, Purkiss AG, Small HF, Stowell AIJ, Thomson GJ, Waddell ID, Waszkowycz B, Watson AJ, Ogilvie DJ. Newton R, et al. Eur J Med Chem. 2016 Apr 13;112:20-32. doi: 10.1016/j.ejmech.2016.01.039. Epub 2016 Jan 29. Eur J Med Chem. 2016. PMID: 26874741 Free PMC article.
Procalcitonin-guided duration of antibiotic treatment in children hospitalised with confirmed or suspected bacterial infection in the UK (BATCH): a pragmatic, multicentre, open-label, two-arm, individually randomised, controlled trial.
Waldron CA, Pallmann P, Schoenbuchner S, Harris D, Brookes-Howell L, Mateus C, Bernatoniene J, Cathie K, Faust SN, Hinds L, Hood K, Huang C, Jones S, Kotecha S, Nabwera HM, Patel S, Paulus SC, Powell CVE, Preston J, Xiang H, Thomas-Jones E, Carrol ED; BATCH Trial Team. Waldron CA, et al. Lancet Child Adolesc Health. 2025 Jan 8:S2352-4642(24)00306-7. doi: 10.1016/S2352-4642(24)00306-7. Online ahead of print. Lancet Child Adolesc Health. 2025. PMID: 39798581 Free article.
The genome sequence of the Shoulder-striped Wainscot moth, Leucania comma Linnaeus, 1761.
Holt S, Sivess L, Januszczak I, Broad GR, Fletcher C, Wawman DC; Natural History Museum Genome Acquisition Lab; University of Oxford and Wytham Woods Genome Acquisition Lab; Darwin Tree of Life Barcoding collective; Wellcome Sanger Institute Tree of Life Management, Samples and Laboratory team; Wellcome Sanger Institute Scientific Operations: Sequencing Operations; Wellcome Sanger Institute Tree of Life Core Informatics team; Tree of Life Core Informatics collective; Darwin Tree of Life Consortium. Holt S, et al. Wellcome Open Res. 2024 Nov 5;9:652. doi: 10.12688/wellcomeopenres.23326.1. eCollection 2024. Wellcome Open Res. 2024. PMID: 39664866 Free PMC article.
The genome sequence of the Common Wainscot moth, Mythimna pallens Linnaeus, 1758.
Holt S, Sivess L, Januszczak I, Broad GR, Fletcher C; Natural History Museum Genome Acquisition Lab; Darwin Tree of Life Barcoding collective; Wellcome Sanger Institute Tree of Life Management, Samples and Laboratory team; Wellcome Sanger Institute Scientific Operations: Sequencing Operations; Wellcome Sanger Institute Tree of Life Core Informatics team; Tree of Life Core Informatics collective; Darwin Tree of Life Consortium. Holt S, et al. Wellcome Open Res. 2024 Nov 6;9:654. doi: 10.12688/wellcomeopenres.23320.1. eCollection 2024. Wellcome Open Res. 2024. PMID: 39649620 Free PMC article.
1,418 results