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Mapping H4K20me3 onto the chromatin landscape of senescent cells indicates a function in control of cell senescence and tumor suppression through preservation of genetic and epigenetic stability.
Nelson DM, Jaber-Hijazi F, Cole JJ, Robertson NA, Pawlikowski JS, Norris KT, Criscione SW, Pchelintsev NA, Piscitello D, Stong N, Rai TS, McBryan T, Otte GL, Nixon C, Clark W, Riethman H, Wu H, Schotta G, Garcia BA, Neretti N, Baird DM, Berger SL, Adams PD. Nelson DM, et al. Among authors: nixon c. Genome Biol. 2016 Jul 25;17(1):158. doi: 10.1186/s13059-016-1017-x. Genome Biol. 2016. PMID: 27457071 Free PMC article.
p53 status determines the role of autophagy in pancreatic tumour development.
Rosenfeldt MT, O'Prey J, Morton JP, Nixon C, MacKay G, Mrowinska A, Au A, Rai TS, Zheng L, Ridgway R, Adams PD, Anderson KI, Gottlieb E, Sansom OJ, Ryan KM. Rosenfeldt MT, et al. Among authors: nixon c. Nature. 2013 Dec 12;504(7479):296-300. doi: 10.1038/nature12865. Epub 2013 Dec 4. Nature. 2013. PMID: 24305049
HIRA orchestrates a dynamic chromatin landscape in senescence and is required for suppression of neoplasia.
Rai TS, Cole JJ, Nelson DM, Dikovskaya D, Faller WJ, Vizioli MG, Hewitt RN, Anannya O, McBryan T, Manoharan I, van Tuyn J, Morrice N, Pchelintsev NA, Ivanov A, Brock C, Drotar ME, Nixon C, Clark W, Sansom OJ, Anderson KI, King A, Blyth K, Adams PD. Rai TS, et al. Among authors: nixon c. Genes Dev. 2014 Dec 15;28(24):2712-25. doi: 10.1101/gad.247528.114. Genes Dev. 2014. PMID: 25512559 Free PMC article.
Acute Inhibition of MEK Suppresses Congenital Melanocytic Nevus Syndrome in a Murine Model Driven by Activated NRAS and Wnt Signaling.
Pawlikowski JS, Brock C, Chen SC, Al-Olabi L, Nixon C, McGregor F, Paine S, Chanudet E, Lambie W, Holmes WM, Mullin JM, Richmond A, Wu H, Blyth K, King A, Kinsler VA, Adams PD. Pawlikowski JS, et al. Among authors: nixon c. J Invest Dermatol. 2015 Aug;135(8):2093-2101. doi: 10.1038/jid.2015.114. Epub 2015 Mar 27. J Invest Dermatol. 2015. PMID: 25815427 Free PMC article.
Mitotic Stress Is an Integral Part of the Oncogene-Induced Senescence Program that Promotes Multinucleation and Cell Cycle Arrest.
Dikovskaya D, Cole JJ, Mason SM, Nixon C, Karim SA, McGarry L, Clark W, Hewitt RN, Sammons MA, Zhu J, Athineos D, Leach JD, Marchesi F, van Tuyn J, Tait SW, Brock C, Morton JP, Wu H, Berger SL, Blyth K, Adams PD. Dikovskaya D, et al. Among authors: nixon c. Cell Rep. 2015 Sep 1;12(9):1483-96. doi: 10.1016/j.celrep.2015.07.055. Epub 2015 Aug 20. Cell Rep. 2015. PMID: 26299965 Free PMC article.
The ERBB network facilitates KRAS-driven lung tumorigenesis.
Kruspig B, Monteverde T, Neidler S, Hock A, Kerr E, Nixon C, Clark W, Hedley A, Laing S, Coffelt SB, Le Quesne J, Dick C, Vousden KH, Martins CP, Murphy DJ. Kruspig B, et al. Among authors: nixon c. Sci Transl Med. 2018 Jun 20;10(446):eaao2565. doi: 10.1126/scitranslmed.aao2565. Sci Transl Med. 2018. PMID: 29925636 Free PMC article.
427 results