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Design and Synthesis of Orally Bioavailable 4-Methyl Heteroaryldihydropyrimidine Based Hepatitis B Virus (HBV) Capsid Inhibitors.
Qiu Z, Lin X, Zhou M, Liu Y, Zhu W, Chen W, Zhang W, Guo L, Liu H, Wu G, Huang M, Jiang M, Xu Z, Zhou Z, Qin N, Ren S, Qiu H, Zhong S, Zhang Y, Zhang Y, Wu X, Shi L, Shen F, Mao Y, Zhou X, Yang W, Wu JZ, Yang G, Mayweg AV, Shen HC, Tang G. Qiu Z, et al. Among authors: chen w. J Med Chem. 2016 Aug 25;59(16):7651-66. doi: 10.1021/acs.jmedchem.6b00879. Epub 2016 Aug 10. J Med Chem. 2016. PMID: 27458651
Discovery of 3-Pyridyl Isoindolin-1-one Derivatives as Potent, Selective, and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors.
Liu Y, Wu J, Zhou M, Chen W, Li D, Wang Z, Hornsperger B, Aebi JD, Märki HP, Kuhn B, Wang L, Kuglstatter A, Benz J, Müller S, Hochstrasser R, Ottaviani G, Xin J, Kirchner S, Mohr S, Verry P, Riboulet W, Shen HC, Mayweg AV, Amrein K, Tan X. Liu Y, et al. Among authors: chen w. J Med Chem. 2020 Jul 9;63(13):6876-6897. doi: 10.1021/acs.jmedchem.0c00233. Epub 2020 Jun 25. J Med Chem. 2020. PMID: 32530624
Discovery of Novel cccDNA Reducers toward the Cure of Hepatitis B Virus Infection.
Chen D, Tan X, Chen W, Liu Y, Li C, Wu J, Zheng J, Shen HC, Zhang M, Wu W, Wang L, Xiong J, Dai J, Sun K, Zhang JD, Xiang K, Li B, Ni X, Zhu Q, Gao L, Wang L, Feng S. Chen D, et al. Among authors: chen w. J Med Chem. 2022 Aug 25;65(16):10938-10955. doi: 10.1021/acs.jmedchem.1c02215. Epub 2022 Aug 16. J Med Chem. 2022. PMID: 35973101
Synthesis, chromatographic resolution, and anti-human immunodeficiency virus activity of (+/-)-calanolide A and its enantiomers.
Flavin MT, Rizzo JD, Khilevich A, Kucherenko A, Sheinkman AK, Vilaychack V, Lin L, Chen W, Greenwood EM, Pengsuparp T, Pezzuto JM, Hughes SH, Flavin TM, Cibulski M, Boulanger WA, Shone RL, Xu ZQ. Flavin MT, et al. Among authors: chen w. J Med Chem. 1996 Mar 15;39(6):1303-13. doi: 10.1021/jm950797i. J Med Chem. 1996. PMID: 8632437
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