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Design and Synthesis of Orally Bioavailable 4-Methyl Heteroaryldihydropyrimidine Based Hepatitis B Virus (HBV) Capsid Inhibitors.
Qiu Z, Lin X, Zhou M, Liu Y, Zhu W, Chen W, Zhang W, Guo L, Liu H, Wu G, Huang M, Jiang M, Xu Z, Zhou Z, Qin N, Ren S, Qiu H, Zhong S, Zhang Y, Zhang Y, Wu X, Shi L, Shen F, Mao Y, Zhou X, Yang W, Wu JZ, Yang G, Mayweg AV, Shen HC, Tang G. Qiu Z, et al. Among authors: qin n. J Med Chem. 2016 Aug 25;59(16):7651-66. doi: 10.1021/acs.jmedchem.6b00879. Epub 2016 Aug 10. J Med Chem. 2016. PMID: 27458651
Discovery and Pre-Clinical Characterization of Third-Generation 4-H Heteroaryldihydropyrimidine (HAP) Analogues as Hepatitis B Virus (HBV) Capsid Inhibitors.
Qiu Z, Lin X, Zhang W, Zhou M, Guo L, Kocer B, Wu G, Zhang Z, Liu H, Shi H, Kou B, Hu T, Hu Y, Huang M, Yan SF, Xu Z, Zhou Z, Qin N, Wang YF, Ren S, Qiu H, Zhang Y, Zhang Y, Wu X, Sun K, Zhong S, Xie J, Ottaviani G, Zhou Y, Zhu L, Tian X, Shi L, Shen F, Mao Y, Zhou X, Gao L, Young JAT, Wu JZ, Yang G, Mayweg AV, Shen HC, Tang G, Zhu W. Qiu Z, et al. Among authors: qin n. J Med Chem. 2017 Apr 27;60(8):3352-3371. doi: 10.1021/acs.jmedchem.7b00083. Epub 2017 Apr 5. J Med Chem. 2017. PMID: 28339215
Discovery of a Novel Respiratory Syncytial Virus Replication Inhibitor.
Wang L, Zhu Q, Xiang K, Zhang Y, Li B, Yu X, Yang G, Liang C, Yun H, Zhang M, Qin N, Gao L. Wang L, et al. Among authors: qin n. Antimicrob Agents Chemother. 2021 May 18;65(6):e02576-20. doi: 10.1128/AAC.02576-20. Print 2021 May 18. Antimicrob Agents Chemother. 2021. PMID: 33782012 Free PMC article.
Novel, broad-spectrum anticonvulsants containing a sulfamide group: advancement of N-((benzo[b]thien-3-yl)methyl)sulfamide (JNJ-26990990) into human clinical studies.
Parker MH, Smith-Swintosky VL, McComsey DF, Huang Y, Brenneman D, Klein B, Malatynska E, White HS, Milewski ME, Herb M, Finley MF, Liu Y, Lubin ML, Qin N, Iannucci R, Leclercq L, Cuyckens F, Reitz AB, Maryanoff BE. Parker MH, et al. Among authors: qin n. J Med Chem. 2009 Dec 10;52(23):7528-36. doi: 10.1021/jm801432r. J Med Chem. 2009. PMID: 19388676
961 results