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Page 1
Identification of potent, selective KDM5 inhibitors.
Gehling VS, Bellon SF, Harmange JC, LeBlanc Y, Poy F, Odate S, Buker S, Lan F, Arora S, Williamson KE, Sandy P, Cummings RT, Bailey CM, Bergeron L, Mao W, Gustafson A, Liu Y, VanderPorten E, Audia JE, Trojer P, Albrecht BK. Gehling VS, et al. Among authors: mao w. Bioorg Med Chem Lett. 2016 Sep 1;26(17):4350-4. doi: 10.1016/j.bmcl.2016.07.026. Epub 2016 Jul 19. Bioorg Med Chem Lett. 2016. PMID: 27476424
Lead optimization of a pyrazolo[1,5-a]pyrimidin-7(4H)-one scaffold to identify potent, selective and orally bioavailable KDM5 inhibitors suitable for in vivo biological studies.
Liang J, Zhang B, Labadie S, Ortwine DF, Vinogradova M, Kiefer JR, Gehling VS, Harmange JC, Cummings R, Lai T, Liao J, Zheng X, Liu Y, Gustafson A, Van der Porten E, Mao W, Liederer BM, Deshmukh G, Classon M, Trojer P, Dragovich PS, Murray L. Liang J, et al. Among authors: mao w. Bioorg Med Chem Lett. 2016 Aug 15;26(16):4036-41. doi: 10.1016/j.bmcl.2016.06.078. Epub 2016 Jun 29. Bioorg Med Chem Lett. 2016. PMID: 27406798
From a novel HTS hit to potent, selective, and orally bioavailable KDM5 inhibitors.
Liang J, Labadie S, Zhang B, Ortwine DF, Patel S, Vinogradova M, Kiefer JR, Mauer T, Gehling VS, Harmange JC, Cummings R, Lai T, Liao J, Zheng X, Liu Y, Gustafson A, Van der Porten E, Mao W, Liederer BM, Deshmukh G, An L, Ran Y, Classon M, Trojer P, Dragovich PS, Murray L. Liang J, et al. Among authors: mao w. Bioorg Med Chem Lett. 2017 Jul 1;27(13):2974-2981. doi: 10.1016/j.bmcl.2017.05.016. Epub 2017 May 5. Bioorg Med Chem Lett. 2017. PMID: 28512031
Discovery and optimization of selective FGFR4 inhibitors via scaffold hopping.
Wang Y, Chen Z, Dai M, Sun P, Wang C, Gao Y, Zhao H, Zeng W, Shen L, Mao W, Wang T, Hu G, Li J, Chen S, Long C, Chen X, Liu J, Zhang Y. Wang Y, et al. Among authors: mao w. Bioorg Med Chem Lett. 2017 Jun 1;27(11):2420-2423. doi: 10.1016/j.bmcl.2017.04.014. Epub 2017 Apr 5. Bioorg Med Chem Lett. 2017. PMID: 28433531
Discovery and Evaluation of Pyrazolo[3,4-d]pyridazinone as a Potent and Orally Active Irreversible BTK Inhibitor.
Zhang X, Sheng X, Shen J, Zhang S, Sun W, Shen C, Li Y, Wang J, Lv H, Cui M, Zhu Y, Huang L, Hao D, Qi Z, Sun G, Mao W, Pan Y, Shen L, Li X, Hu G, Gong Z, Han S, Li J, Chen S, Tu R, Wang X, Wu C. Zhang X, et al. Among authors: mao w. ACS Med Chem Lett. 2019 Dec 11;11(10):1863-1868. doi: 10.1021/acsmedchemlett.9b00395. eCollection 2020 Oct 8. ACS Med Chem Lett. 2019. PMID: 33062165 Free PMC article.
iMeta Conference 2024: Building an innovative scientific research ecosystem for microbiome and One Health.
Wang Y, Hou H, Luo H, Xun J, Ma C, Yang H, Bai D, Yousuf S, Lyu H, Zhang T, Wan X, Yao X, Ma T, Zhou Y, Zhu Z, Zeng M, An S, Bai Q, Bai Y, Cao G, Cao T, Cao Y, Chang C, Chang L, Chen B, Chen D, Chen D, Chen H, Chen J, Chen J, Chen WH, Chen X, Chen Y, Chen Z, Cheng C, Cheng Q, Dai XJ, Deng C, Deng F, Deng J, Dong CS, Dong L, Duan L, Duan Y, Fan Q, Fang C, Fang T, Fang W, Fang Z, Fu M, Fu M, Gao C, Gao H, Gao W, Gao X, Gao YZ, Geng Y, Gong W, Gu S, Gu X, Gu Z, Guo JW, Guo J, Guo Q, Guo X, Guo X, Han D, Han Z, Hao Y, He J, He J, He J, He R, Hou G, Hu B, Hu H, Hu Y, Hu Y, Hu Y, Huang G, Huang H, Huang J, Huang S, Jia B, Jian X, Jiang C, Jiang K, Jiang L, Jiang S, Jiao JY, Jin H, Jin J, Kong S, Lai X, Leng Y, Li B, Li B, Li F, Li H, Li H, Li J, Li K, Li L, Li L, Li M, Li P, Li W, Li W, Li X, Xuemeng L, Li Y, Li Y, Li Z, Liang L, Liang R, Liang Z, Liu Q, Liu D, Liu H, Liu J, Liu L, Liu L, Liu M, Liu R, Liu S, Liu T, Liu W, Liu W, Liu X, Liu Y, Liu Y, Liu Y, Liu Y, Liu Z, Liu Z, Liu Z, Long C, Long Y, Lu C, Lu C, Lu C, Lu Q, Luan Y, Luo P, Luo S, Ma N, Ma XY, Ma Y, Mao W, Meng Y, Ni Y, Ni Y, Ning K, Niu D, Peng K, Peng Z, Qian X, Qiu Z, Qu H, Qu Z, Ren Y, Ren Z, Shen Y, Shi L, Shi… See abstract for full author list ➔ Wang Y, et al. Among authors: mao w. Imeta. 2024 Dec 15;3(6):e251. doi: 10.1002/imt2.251. eCollection 2024 Dec. Imeta. 2024. PMID: 39742310 Free PMC article.
3,024 results