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Tyrosine Kinase Inhibitors. 20. Optimization of Substituted Quinazoline and Pyrido[3,4-d]pyrimidine Derivatives as Orally Active, Irreversible Inhibitors of the Epidermal Growth Factor Receptor Family.
Smaill JB, Gonzales AJ, Spicer JA, Lee H, Reed JE, Sexton K, Althaus IW, Zhu T, Black SL, Blaser A, Denny WA, Ellis PA, Fakhoury S, Harvey PJ, Hook K, McCarthy FO, Palmer BD, Rivault F, Schlosser K, Ellis T, Thompson AM, Trachet E, Winters RT, Tecle H, Bridges A. Smaill JB, et al. Among authors: sexton k. J Med Chem. 2016 Sep 8;59(17):8103-24. doi: 10.1021/acs.jmedchem.6b00883. Epub 2016 Aug 22. J Med Chem. 2016. PMID: 27491023
Antitumor activity and pharmacokinetic properties of PF-00299804, a second-generation irreversible pan-erbB receptor tyrosine kinase inhibitor.
Gonzales AJ, Hook KE, Althaus IW, Ellis PA, Trachet E, Delaney AM, Harvey PJ, Ellis TA, Amato DM, Nelson JM, Fry DW, Zhu T, Loi CM, Fakhoury SA, Schlosser KM, Sexton KE, Winters RT, Reed JE, Bridges AJ, Lettiere DJ, Baker DA, Yang J, Lee HT, Tecle H, Vincent PW. Gonzales AJ, et al. Mol Cancer Ther. 2008 Jul;7(7):1880-9. doi: 10.1158/1535-7163.MCT-07-2232. Epub 2008 Jul 7. Mol Cancer Ther. 2008. PMID: 18606718
Inhibitors of lipoprotein(a) assembly.
Sexton KE, Lee HT, Massa M, Padia J, Patt WC, Liao P, Pontrello JK, Roth BD, Spahr MA, Ramharack R. Sexton KE, et al. Bioorg Med Chem. 2003 Nov 3;11(22):4827-45. doi: 10.1016/j.bmc.2002.04.001. Bioorg Med Chem. 2003. PMID: 14556799
Discovery of a series of 2-(1H-pyrazol-1-yl)pyridines as ALK5 inhibitors with potential utility in the prevention of dermal scarring.
Boys ML, Bian F, Kramer JB, Chio CL, Ren XD, Chen H, Barrett SD, Sexton KE, Iula DM, Filzen GF, Nguyen MN, Angell P, Downs VL, Wang Z, Raheja N, Ellsworth EL, Fakhoury S, Bratton LD, Keller PR, Gowan R, Drummond EM, Maiti SN, Hena MA, Lu L, McConnell P, Knafels JD, Thanabal V, Sun F, Alessi D, McCarthy A, Zhang E, Finzel BC, Patel S, Ciotti SM, Eisma R, Payne NA, Gilbertsen RB, Kostlan CR, Pocalyko DJ, Lala DS. Boys ML, et al. Bioorg Med Chem Lett. 2012 May 15;22(10):3392-7. doi: 10.1016/j.bmcl.2012.04.013. Epub 2012 Apr 10. Bioorg Med Chem Lett. 2012. PMID: 22542194
Rational design of a topical androgen receptor antagonist for the suppression of sebum production with properties suitable for follicular delivery.
Mitchell LH, Johnson TR, Lu GW, Du D, Datta K, Grzemski F, Shanmugasundaram V, Spence J, Wade K, Wang Z, Sun K, Lin K, Hu LY, Sexton K, Raheja N, Kostlan C, Pocalyko D. Mitchell LH, et al. Among authors: sexton k. J Med Chem. 2010 Jun 10;53(11):4422-7. doi: 10.1021/jm9018004. J Med Chem. 2010. PMID: 20462217
ImpENSA eHealthy Conversation Skills training for healthcare professionals aimed at improving micronutrient status during the first 1000 days in South Africa.
Patro-Golab B, Choi S, Lukasik J, Walsh C, Kolodziej M, Havemann-Nel L, Venter E, Sexton K, Omer S, Goddard L, Godfrey KM, Lawrence W, Koletzko B; ImpENSA Study Group. Patro-Golab B, et al. Among authors: sexton k. PLOS Glob Public Health. 2024 Dec 4;4(12):e0003833. doi: 10.1371/journal.pgph.0003833. eCollection 2024. PLOS Glob Public Health. 2024. PMID: 39630684 Free PMC article.
The MED13L Foundation strategic research plan: a roadmap to the future.
Heilmann R, Pfalzer A, Bichell TJ, Terala A, Campbell A, Taatjes D, Ghoumid J, Grueter C, Bain J, Strich R, Dias V, Sokorai K, Seaver N, Sexton K, Boychuck K. Heilmann R, et al. Among authors: sexton k. Ther Adv Rare Dis. 2024 Nov 28;5:26330040241290252. doi: 10.1177/26330040241290252. eCollection 2024 Jan-Dec. Ther Adv Rare Dis. 2024. PMID: 39619418 Free PMC article.
425 results