Blumberg PM - Search Results

1

Synthesis and Biological Evaluation of Several Bryostatin Analogues Bearing a Diacylglycerol Lactone C-Ring.

Baumann DO, McGowan KM, Kedei N, Peach ML, Blumberg PM, Keck GE. Baumann DO, et al. Among authors: blumberg pm. J Org Chem. 2016 Sep 2;81(17):7862-83. doi: 10.1021/acs.joc.6b01516. Epub 2016 Aug 23. J Org Chem. 2016. PMID: 27494208 Free PMC article.

2

Differential binding modes of diacylglycerol (DAG) and DAG lactones to protein kinase C (PK-C).

Sigano DM, Peach ML, Nacro K, Choi Y, Lewin NE, Nicklaus MC, Blumberg PM, Marquez VE. Sigano DM, et al. Among authors: blumberg pm. J Med Chem. 2003 Apr 24;46(9):1571-9. doi: 10.1021/jm020476o. J Med Chem. 2003. PMID: 12699375

3

Conformationally constrained analogues of diacylglycerol (DAG). 25. Exploration of the sn-1 and sn-2 carbonyl functionality reveals the essential role of the sn-1 carbonyl at the lipid interface in the binding of DAG-lactones to protein kinase C.

Kang JH, Peach ML, Pu Y, Lewin NE, Nicklaus MC, Blumberg PM, Marquez VE. Kang JH, et al. Among authors: blumberg pm. J Med Chem. 2005 Sep 8;48(18):5738-48. doi: 10.1021/jm050352m. J Med Chem. 2005. PMID: 16134942 Free PMC article.

4

Conformationally constrained analogues of diacylglycerol. 26. Exploring the chemical space surrounding the C1 domain of protein kinase C with DAG-lactones containing aryl groups at the sn-1 and sn-2 positions.

Kang JH, Benzaria S, Sigano DM, Lewin NE, Pu Y, Peach ML, Blumberg PM, Marquez VE. Kang JH, et al. Among authors: blumberg pm. J Med Chem. 2006 Jun 1;49(11):3185-203. doi: 10.1021/jm060011o. J Med Chem. 2006. PMID: 16722637

5

Convergent assembly of highly potent analogues of bryostatin 1 via pyran annulation: bryostatin look-alikes that mimic phorbol ester function.

Keck GE, Kraft MB, Truong AP, Li W, Sanchez CC, Kedei N, Lewin NE, Blumberg PM. Keck GE, et al. Among authors: blumberg pm. J Am Chem Soc. 2008 May 28;130(21):6660-1. doi: 10.1021/ja8022169. Epub 2008 May 2. J Am Chem Soc. 2008. PMID: 18452293 Free PMC article.

6

Conformationally constrained analogues of diacylglycerol. 29. Cells sort diacylglycerol-lactone chemical zip codes to produce diverse and selective biological activities.

Duan D, Sigano DM, Kelley JA, Lai CC, Lewin NE, Kedei N, Peach ML, Lee J, Abeyweera TP, Rotenberg SA, Kim H, Kim YH, El Kazzouli S, Chung JU, Young HA, Young MR, Baker A, Colburn NH, Haimovitz-Friedman A, Truman JP, Parrish DA, Deschamps JR, Perry NA, Surawski RJ, Blumberg PM, Marquez VE. Duan D, et al. Among authors: blumberg pm. J Med Chem. 2008 Sep 11;51(17):5198-220. doi: 10.1021/jm8001907. Epub 2008 Aug 13. J Med Chem. 2008. PMID: 18698758 Free PMC article.

7

Substitution on the A-ring confers to bryopyran analogues the unique biological activity characteristic of bryostatins and distinct from that of the phorbol esters.

Keck GE, Poudel YB, Welch DS, Kraft MB, Truong AP, Stephens JC, Kedei N, Lewin NE, Blumberg PM. Keck GE, et al. Among authors: blumberg pm. Org Lett. 2009 Feb 5;11(3):593-6. doi: 10.1021/ol8027253. Org Lett. 2009. PMID: 19113896 Free PMC article.

8

The bryostatin 1 A-ring acetate is not the critical determinant for antagonism of phorbol ester-induced biological responses.

Keck GE, Li W, Kraft MB, Kedei N, Lewin NE, Blumberg PM. Keck GE, et al. Among authors: blumberg pm. Org Lett. 2009 Jun 4;11(11):2277-80. doi: 10.1021/ol900585t. Org Lett. 2009. PMID: 19419164 Free PMC article.

9

Molecular modeling, total synthesis, and biological evaluations of C9-deoxy bryostatin 1.

Keck GE, Poudel YB, Rudra A, Stephens JC, Kedei N, Lewin NE, Peach ML, Blumberg PM. Keck GE, et al. Among authors: blumberg pm. Angew Chem Int Ed Engl. 2010 Jun 21;49(27):4580-4. doi: 10.1002/anie.201001200. Angew Chem Int Ed Engl. 2010. PMID: 20491108 Free PMC article. No abstract available.

10

Role of the C8 gem-dimethyl group of bryostatin 1 on its unique pattern of biological activity.

Keck GE, Poudel YB, Rudra A, Stephens JC, Kedei N, Lewin NE, Blumberg PM. Keck GE, et al. Among authors: blumberg pm. Bioorg Med Chem Lett. 2012 Jun 15;22(12):4084-8. doi: 10.1016/j.bmcl.2012.04.073. Epub 2012 Apr 24. Bioorg Med Chem Lett. 2012. PMID: 22579485 Free PMC article.

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