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Profiling of the Bcl-2/Bcl-X(L)-binding sites on type 1 IP(3) receptor.
Monaco G, Beckers M, Ivanova H, Missiaen L, Parys JB, De Smedt H, Bultynck G. Monaco G, et al. Among authors: de smedt h. Biochem Biophys Res Commun. 2012 Nov 9;428(1):31-5. doi: 10.1016/j.bbrc.2012.10.002. Epub 2012 Oct 8. Biochem Biophys Res Commun. 2012. PMID: 23058917
Li, K. McColl, S. Matsuyama, S. Herlitze, H.L. Roderick, M.D. Bootman, G.A. Mignery, J.B. Parys, H. De Smedt, C.W. Distelhorst, Targeting Bcl-2-IP3 receptor interaction to reverse Bcl-2's inhibition of apoptotic calcium signals, Mol. ...
Li, K. McColl, S. Matsuyama, S. Herlitze, H.L. Roderick, M.D. Bootman, G.A. Mignery, J.B. Parys, H. De Smedt, C. …
Alpha-helical destabilization of the Bcl-2-BH4-domain peptide abolishes its ability to inhibit the IP3 receptor.
Monaco G, Decrock E, Nuyts K, Wagner LE 2nd, Luyten T, Strelkov SV, Missiaen L, De Borggraeve WM, Leybaert L, Yule DI, De Smedt H, Parys JB, Bultynck G. Monaco G, et al. Among authors: de smedt h, de borggraeve wm. PLoS One. 2013 Aug 30;8(8):e73386. doi: 10.1371/journal.pone.0073386. eCollection 2013. PLoS One. 2013. PMID: 24137498 Free PMC article.
Bcl-2 and IP3 compete for the ligand-binding domain of IP3Rs modulating Ca2+ signaling output.
Ivanova H, Wagner LE 2nd, Tanimura A, Vandermarliere E, Luyten T, Welkenhuyzen K, Alzayady KJ, Wang L, Hamada K, Mikoshiba K, De Smedt H, Martens L, Yule DI, Parys JB, Bultynck G. Ivanova H, et al. Among authors: de smedt h. Cell Mol Life Sci. 2019 Oct;76(19):3843-3859. doi: 10.1007/s00018-019-03091-8. Epub 2019 Apr 16. Cell Mol Life Sci. 2019. PMID: 30989245 Free PMC article.
Selective regulation of IP3-receptor-mediated Ca2+ signaling and apoptosis by the BH4 domain of Bcl-2 versus Bcl-Xl.
Monaco G, Decrock E, Akl H, Ponsaerts R, Vervliet T, Luyten T, De Maeyer M, Missiaen L, Distelhorst CW, De Smedt H, Parys JB, Leybaert L, Bultynck G. Monaco G, et al. Among authors: de smedt h, de maeyer m. Cell Death Differ. 2012 Feb;19(2):295-309. doi: 10.1038/cdd.2011.97. Epub 2011 Aug 5. Cell Death Differ. 2012. PMID: 21818117 Free PMC article.
Binding of IRBIT to the IP3 receptor: determinants and functional effects.
Devogelaere B, Nadif Kasri N, Derua R, Waelkens E, Callewaert G, Missiaen L, Parys JB, De Smedt H. Devogelaere B, et al. Among authors: de smedt h. Biochem Biophys Res Commun. 2006 Apr 28;343(1):49-56. doi: 10.1016/j.bbrc.2006.02.119. Epub 2006 Feb 28. Biochem Biophys Res Commun. 2006. PMID: 16527252
242 results