Convergent synthesis and in vivo inhibitory effect on fat accumulation of (-)-ternatin, a highly N-methylated cyclic peptide.
Shimokawa K, Yamada K, Kita M, Uemura D.
Shimokawa K, et al. Among authors: kita m.
Bioorg Med Chem Lett. 2007 Aug 15;17(16):4447-9. doi: 10.1016/j.bmcl.2007.06.015. Epub 2007 Jun 8.
Bioorg Med Chem Lett. 2007.
PMID: 17590333
(-)-Ternatin (1), a highly N-methylated cyclic heptapeptide, is a potent inhibitor of fat accumulation against 3T3-L1 murine adipocytes (EC50 = 0.14 microg/mL) [Shimokawa, K.; Mashima, I.; Asai, A.; Yamada, K.; Kita, M.; Uemura, D. Tetrahedron Lett. 2006, 47, 4445]. …
(-)-Ternatin (1), a highly N-methylated cyclic heptapeptide, is a potent inhibitor of fat accumulation against 3T3-L1 murine adipocytes (EC5 …