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Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer's disease in rodent models.
Daniels MJ, Rivers-Auty J, Schilling T, Spencer NG, Watremez W, Fasolino V, Booth SJ, White CS, Baldwin AG, Freeman S, Wong R, Latta C, Yu S, Jackson J, Fischer N, Koziel V, Pillot T, Bagnall J, Allan SM, Paszek P, Galea J, Harte MK, Eder C, Lawrence CB, Brough D. Daniels MJ, et al. Among authors: lawrence cb. Nat Commun. 2016 Aug 11;7:12504. doi: 10.1038/ncomms12504. Nat Commun. 2016. PMID: 27509875 Free PMC article.
IL-1Rrp2 expression and IL-1F9 (IL-1H1) actions in brain cells.
Berglöf E, Andre R, Renshaw BR, Allan SM, Lawrence CB, Rothwell NJ, Pinteaux E. Berglöf E, et al. Among authors: lawrence cb. J Neuroimmunol. 2003 Jun;139(1-2):36-43. doi: 10.1016/s0165-5728(03)00130-9. J Neuroimmunol. 2003. PMID: 12799018
Zinc depletion regulates the processing and secretion of IL-1β.
Summersgill H, England H, Lopez-Castejon G, Lawrence CB, Luheshi NM, Pahle J, Mendes P, Brough D. Summersgill H, et al. Among authors: lawrence cb. Cell Death Dis. 2014 Jan 30;5(1):e1040. doi: 10.1038/cddis.2013.547. Cell Death Dis. 2014. PMID: 24481454 Free PMC article.
183 results