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Serine 421 regulates mutant huntingtin toxicity and clearance in mice.
Kratter IH, Zahed H, Lau A, Tsvetkov AS, Daub AC, Weiberth KF, Gu X, Saudou F, Humbert S, Yang XW, Osmand A, Steffan JS, Masliah E, Finkbeiner S. Kratter IH, et al. Among authors: humbert s. J Clin Invest. 2016 Sep 1;126(9):3585-97. doi: 10.1172/JCI80339. Epub 2016 Aug 15. J Clin Invest. 2016. PMID: 27525439 Free PMC article.
Toward cell specificity in SCA1.
Humbert S, Saudou F. Humbert S, et al. Neuron. 2002 May 30;34(5):669-70. doi: 10.1016/s0896-6273(02)00715-8. Neuron. 2002. PMID: 12062012 Free article. Review.
[Stimulation of BDNF transport by huntingtin].
Humbert S, Saudou F. Humbert S, et al. Med Sci (Paris). 2004 Nov;20(11):952-4. doi: 10.1051/medsci/20042011952. Med Sci (Paris). 2004. PMID: 15525484 Free article. French. No abstract available.
Phosphorylation of arfaptin 2 at Ser260 by Akt Inhibits PolyQ-huntingtin-induced toxicity by rescuing proteasome impairment.
Rangone H, Pardo R, Colin E, Girault JA, Saudou F, Humbert S. Rangone H, et al. Among authors: humbert s. J Biol Chem. 2005 Jun 10;280(23):22021-8. doi: 10.1074/jbc.M407528200. Epub 2005 Apr 4. J Biol Chem. 2005. PMID: 15809304 Free article.
This neuroprotective effect involves the phosphorylation of huntingtin at Ser(421) by the prosurvival kinase Akt (Humbert, S., Bryson, E. A., Cordelieres, F. P., Connors, N. C., Datta, S. R., Finkbeiner, S., Greenberg, M. ...Here, we report that Akt in …
This neuroprotective effect involves the phosphorylation of huntingtin at Ser(421) by the prosurvival kinase Akt (Humbert, S., …
Akt is altered in an animal model of Huntington's disease and in patients.
Colin E, Régulier E, Perrin V, Dürr A, Brice A, Aebischer P, Déglon N, Humbert S, Saudou F. Colin E, et al. Among authors: humbert s. Eur J Neurosci. 2005 Mar;21(6):1478-88. doi: 10.1111/j.1460-9568.2005.03985.x. Eur J Neurosci. 2005. PMID: 15845076
The insulin-like growth factor I (IGF-1)/Akt pathway plays a crucial role in Huntington's disease by phosphorylating the causative protein, polyQ-huntingtin, and abolishing its toxic properties [Humbert et al. (2002)Dev. ...In the present report, we thus aimed to an …
The insulin-like growth factor I (IGF-1)/Akt pathway plays a crucial role in Huntington's disease by phosphorylating the causative pr …
185 results