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Serotonin engages an anxiety and fear-promoting circuit in the extended amygdala.
Marcinkiewcz CA, Mazzone CM, D'Agostino G, Halladay LR, Hardaway JA, DiBerto JF, Navarro M, Burnham N, Cristiano C, Dorrier CE, Tipton GJ, Ramakrishnan C, Kozicz T, Deisseroth K, Thiele TE, McElligott ZA, Holmes A, Heisler LK, Kash TL. Marcinkiewcz CA, et al. Among authors: heisler lk. Nature. 2016 Sep 1;537(7618):97-101. doi: 10.1038/nature19318. Epub 2016 Aug 24. Nature. 2016. PMID: 27556938 Free PMC article.
5-HT obesity medication efficacy via POMC activation is maintained during aging.
Burke LK, Doslikova B, D'Agostino G, Garfield AS, Farooq G, Burdakov D, Low MJ, Rubinstein M, Evans ML, Billups B, Heisler LK. Burke LK, et al. Among authors: heisler lk. Endocrinology. 2014 Oct;155(10):3732-8. doi: 10.1210/en.2014-1223. Epub 2014 Jul 22. Endocrinology. 2014. PMID: 25051442 Free PMC article.
Leptin-inhibited PBN neurons enhance responses to hypoglycemia in negative energy balance.
Flak JN, Patterson CM, Garfield AS, D'Agostino G, Goforth PB, Sutton Hickey AK, Malec PA, Wong JT, Germani M, Jones JC, Rajala M, Satin L, Rhodes CJ, Olson DP, Kennedy RT, Heisler LK, Myers MG Jr. Flak JN, et al. Among authors: heisler lk. Nat Neurosci. 2014 Dec;17(12):1744-1750. doi: 10.1038/nn.3861. Epub 2014 Nov 10. Nat Neurosci. 2014. PMID: 25383904 Free PMC article.
Lorcaserin improves glycemic control via a melanocortin neurocircuit.
Burke LK, Ogunnowo-Bada E, Georgescu T, Cristiano C, de Morentin PBM, Valencia Torres L, D'Agostino G, Riches C, Heeley N, Ruan Y, Rubinstein M, Low MJ, Myers MG, Rochford JJ, Evans ML, Heisler LK. Burke LK, et al. Among authors: heisler lk. Mol Metab. 2017 Oct;6(10):1092-1102. doi: 10.1016/j.molmet.2017.07.004. Epub 2017 Jul 21. Mol Metab. 2017. PMID: 29031711 Free PMC article.
Nucleus of the Solitary Tract Serotonin 5-HT2C Receptors Modulate Food Intake.
D'Agostino G, Lyons D, Cristiano C, Lettieri M, Olarte-Sanchez C, Burke LK, Greenwald-Yarnell M, Cansell C, Doslikova B, Georgescu T, Martinez de Morentin PB, Myers MG Jr, Rochford JJ, Heisler LK. D'Agostino G, et al. Among authors: heisler lk. Cell Metab. 2018 Oct 2;28(4):619-630.e5. doi: 10.1016/j.cmet.2018.07.017. Epub 2018 Aug 23. Cell Metab. 2018. PMID: 30146485 Free PMC article.
Obesity medication lorcaserin activates brainstem GLP-1 neurons to reduce food intake and augments GLP-1 receptor agonist induced appetite suppression.
Wagner S, Brierley DI, Leeson-Payne A, Jiang W, Chianese R, Lam BYH, Dowsett GKC, Cristiano C, Lyons D, Reimann F, Gribble FM, Martinez de Morentin PB, Yeo GSH, Trapp S, Heisler LK. Wagner S, et al. Among authors: heisler lk. Mol Metab. 2023 Feb;68:101665. doi: 10.1016/j.molmet.2022.101665. Epub 2022 Dec 30. Mol Metab. 2023. PMID: 36592795 Free PMC article.
Serotonin 5-HT(2C) receptors regulate anxiety-like behavior.
Heisler LK, Zhou L, Bajwa P, Hsu J, Tecott LH. Heisler LK, et al. Genes Brain Behav. 2007 Jul;6(5):491-6. doi: 10.1111/j.1601-183X.2007.00316.x. Epub 2007 Apr 19. Genes Brain Behav. 2007. PMID: 17451451 Free article.
81 results