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Clinical Actionability of Comprehensive Genomic Profiling for Management of Rare or Refractory Cancers.
Hirshfield KM, Tolkunov D, Zhong H, Ali SM, Stein MN, Murphy S, Vig H, Vazquez A, Glod J, Moss RA, Belyi V, Chan CS, Chen S, Goodell L, Foran D, Yelensky R, Palma NA, Sun JX, Miller VA, Stephens PJ, Ross JS, Kaufman H, Poplin E, Mehnert J, Tan AR, Bertino JR, Aisner J, DiPaola RS, Rodriguez-Rodriguez L, Ganesan S. Hirshfield KM, et al. Among authors: chen s. Oncologist. 2016 Nov;21(11):1315-1325. doi: 10.1634/theoncologist.2016-0049. Epub 2016 Aug 26. Oncologist. 2016. PMID: 27566247 Free PMC article.
Metabotropic glutamate receptor 1 expression and its polymorphic variants associate with breast cancer phenotypes.
Mehta MS, Dolfi SC, Bronfenbrener R, Bilal E, Chen C, Moore D, Lin Y, Rahim H, Aisner S, Kersellius RD, Teh J, Chen S, Toppmeyer DL, Medina DJ, Ganesan S, Vazquez A, Hirshfield KM. Mehta MS, et al. Among authors: chen c, chen s. PLoS One. 2013 Jul 26;8(7):e69851. doi: 10.1371/journal.pone.0069851. Print 2013. PLoS One. 2013. PMID: 23922822 Free PMC article.
Metabotropic glutamate receptor 1 disrupts mammary acinar architecture and initiates malignant transformation of mammary epithelial cells.
Teh JL, Shah R, La Cava S, Dolfi SC, Mehta MS, Kongara S, Price S, Ganesan S, Reuhl KR, Hirshfield KM, Karantza V, Chen S. Teh JL, et al. Among authors: chen s. Breast Cancer Res Treat. 2015 May;151(1):57-73. doi: 10.1007/s10549-015-3365-8. Epub 2015 Apr 10. Breast Cancer Res Treat. 2015. PMID: 25859923 Free PMC article.
A phase 0 trial of riluzole in patients with resectable stage III and IV melanoma.
Yip D, Le MN, Chan JL, Lee JH, Mehnert JA, Yudd A, Kempf J, Shih WJ, Chen S, Goydos JS. Yip D, et al. Among authors: chen s. Clin Cancer Res. 2009 Jun 1;15(11):3896-902. doi: 10.1158/1078-0432.CCR-08-3303. Epub 2009 May 19. Clin Cancer Res. 2009. PMID: 19458050 Free PMC article. Clinical Trial.
The transcription factor RUNX2 regulates receptor tyrosine kinase expression in melanoma.
Boregowda RK, Medina DJ, Markert E, Bryan MA, Chen W, Chen S, Rabkin A, Vido MJ, Gunderson SI, Chekmareva M, Foran DJ, Lasfar A, Goydos JS, Cohen-Solal KA. Boregowda RK, et al. Among authors: chen s, chen w. Oncotarget. 2016 May 17;7(20):29689-707. doi: 10.18632/oncotarget.8822. Oncotarget. 2016. PMID: 27102439 Free PMC article.
A phase II trial of riluzole, an antagonist of metabotropic glutamate receptor 1 (GRM1) signaling, in patients with advanced melanoma.
Mehnert JM, Silk AW, Lee JH, Dudek L, Jeong BS, Li J, Schenkel JM, Sadimin E, Kane M, Lin H, Shih WJ, Zloza A, Chen S, Goydos JS. Mehnert JM, et al. Among authors: chen s. Pigment Cell Melanoma Res. 2018 Jul;31(4):534-540. doi: 10.1111/pcmr.12694. Epub 2018 Apr 10. Pigment Cell Melanoma Res. 2018. PMID: 29453787 Free PMC article. Clinical Trial.
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