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Discovery of 8-Trifluoromethyl-3-cyclopropylmethyl-7-[(4-(2,4-difluorophenyl)-1-piperazinyl)methyl]-1,2,4-triazolo[4,3-a]pyridine (JNJ-46356479), a Selective and Orally Bioavailable mGlu2 Receptor Positive Allosteric Modulator (PAM).
Cid JM, Tresadern G, Vega JA, de Lucas AI, Del Cerro A, Matesanz E, Linares ML, García A, Iturrino L, Pérez-Benito L, Macdonald GJ, Oehlrich D, Lavreysen H, Peeters L, Ceusters M, Ahnaou A, Drinkenburg W, Mackie C, Somers M, Trabanco AA. Cid JM, et al. J Med Chem. 2016 Sep 22;59(18):8495-507. doi: 10.1021/acs.jmedchem.6b00913. Epub 2016 Sep 9. J Med Chem. 2016. PMID: 27579727
The size matters? A computational tool to design bivalent ligands.
Pérez-Benito L, Henry A, Matsoukas MT, Lopez L, Pulido D, Royo M, Cordomí A, Tresadern G, Pardo L. Pérez-Benito L, et al. Bioinformatics. 2018 Nov 15;34(22):3857-3863. doi: 10.1093/bioinformatics/bty422. Bioinformatics. 2018. PMID: 29850769 Free PMC article.
44 results