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Increased neuronal PreP activity reduces Aβ accumulation, attenuates neuroinflammation and improves mitochondrial and synaptic function in Alzheimer disease's mouse model.
Fang D, Wang Y, Zhang Z, Du H, Yan S, Sun Q, Zhong C, Wu L, Vangavaragu JR, Yan S, Hu G, Guo L, Rabinowitz M, Glaser E, Arancio O, Sosunov AA, McKhann GM, Chen JX, Yan SS. Fang D, et al. Among authors: yan ss, yan s. Hum Mol Genet. 2015 Sep 15;24(18):5198-210. doi: 10.1093/hmg/ddv241. Epub 2015 Jun 29. Hum Mol Genet. 2015. PMID: 26123488 Free PMC article.
PP2A methylation controls sensitivity and resistance to β-amyloid-induced cognitive and electrophysiological impairments.
Nicholls RE, Sontag JM, Zhang H, Staniszewski A, Yan S, Kim CY, Yim M, Woodruff CM, Arning E, Wasek B, Yin D, Bottiglieri T, Sontag E, Kandel ER, Arancio O. Nicholls RE, et al. Among authors: yan s. Proc Natl Acad Sci U S A. 2016 Mar 22;113(12):3347-52. doi: 10.1073/pnas.1521018113. Epub 2016 Mar 7. Proc Natl Acad Sci U S A. 2016. PMID: 26951658 Free PMC article.
Identification of a Novel 1,2,3,4-Tetrahydrobenzo[b][1,6]naphthyridine Analogue as a Potent Phosphodiesterase 5 Inhibitor with Improved Aqueous Solubility for the Treatment of Alzheimer's Disease.
Fiorito J, Vendome J, Saeed F, Staniszewski A, Zhang H, Yan S, Deng SX, Arancio O, Landry DW. Fiorito J, et al. Among authors: yan s. J Med Chem. 2017 Nov 9;60(21):8858-8875. doi: 10.1021/acs.jmedchem.7b00979. Epub 2017 Oct 23. J Med Chem. 2017. PMID: 28985058 Free PMC article.
Mitochondrial Perturbation in Alzheimer's Disease and Diabetes.
Akhter F, Chen D, Yan SF, Yan SS. Akhter F, et al. Among authors: yan ss, yan sf. Prog Mol Biol Transl Sci. 2017;146:341-361. doi: 10.1016/bs.pmbts.2016.12.019. Epub 2017 Feb 4. Prog Mol Biol Transl Sci. 2017. PMID: 28253990 Free PMC article. Review.
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