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Glioma-induced inhibition of caspase-3 in microglia promotes a tumor-supportive phenotype.
Shen X, Burguillos MA, Osman AM, Frijhoff J, Carrillo-Jiménez A, Kanatani S, Augsten M, Saidi D, Rodhe J, Kavanagh E, Rongvaux A, Rraklli V, Nyman U, Holmberg J, Östman A, Flavell RA, Barragan A, Venero JL, Blomgren K, Joseph B. Shen X, et al. Among authors: holmberg j. Nat Immunol. 2016 Nov;17(11):1282-1290. doi: 10.1038/ni.3545. Epub 2016 Sep 12. Nat Immunol. 2016. PMID: 27618552 Free article.
A chemical screen identifies trifluoperazine as an inhibitor of glioblastoma growth.
Pinheiro T, Otrocka M, Seashore-Ludlow B, Rraklli V, Holmberg J, Forsberg-Nilsson K, Simon A, Kirkham M. Pinheiro T, et al. Among authors: holmberg j. Biochem Biophys Res Commun. 2017 Dec 16;494(3-4):477-483. doi: 10.1016/j.bbrc.2017.10.106. Epub 2017 Oct 21. Biochem Biophys Res Commun. 2017. PMID: 29066348
Combined epigenetic and differentiation-based treatment inhibits neuroblastoma tumor growth and links HIF2α to tumor suppression.
Westerlund I, Shi Y, Toskas K, Fell SM, Li S, Surova O, Södersten E, Kogner P, Nyman U, Schlisio S, Holmberg J. Westerlund I, et al. Among authors: holmberg j. Proc Natl Acad Sci U S A. 2017 Jul 25;114(30):E6137-E6146. doi: 10.1073/pnas.1700655114. Epub 2017 Jul 10. Proc Natl Acad Sci U S A. 2017. PMID: 28696319 Free PMC article.
Aberrant splicing in neuroblastoma generates RNA-fusion transcripts and provides vulnerability to spliceosome inhibitors.
Shi Y, Yuan J, Rraklli V, Maxymovitz E, Cipullo M, Liu M, Li S, Westerlund I, Bedoya-Reina OC, Bullova P, Rorbach J, Juhlin CC, Stenman A, Larsson C, Kogner P, O'Sullivan MJ, Schlisio S, Holmberg J. Shi Y, et al. Among authors: holmberg j. Nucleic Acids Res. 2021 Mar 18;49(5):2509-2521. doi: 10.1093/nar/gkab054. Nucleic Acids Res. 2021. PMID: 33555349 Free PMC article.
NCoR controls glioblastoma tumor cell characteristics.
Heldring N, Nyman U, Lönnerberg P, Onnestam S, Herland A, Holmberg J, Hermanson O. Heldring N, et al. Among authors: holmberg j. Neuro Oncol. 2014 Jan;16(2):241-9. doi: 10.1093/neuonc/not214. Epub 2013 Dec 12. Neuro Oncol. 2014. PMID: 24335696 Free PMC article.
287 results