Giaccia AJ - Search Results

1

Identification of Doxorubicin as an Inhibitor of the IRE1α-XBP1 Axis of the Unfolded Protein Response.

Jiang D, Lynch C, Medeiros BC, Liedtke M, Bam R, Tam AB, Yang Z, Alagappan M, Abidi P, Le QT, Giaccia AJ, Denko NC, Niwa M, Koong AC. Jiang D, et al. Among authors: giaccia aj. Sci Rep. 2016 Sep 16;6:33353. doi: 10.1038/srep33353. Sci Rep. 2016. PMID: 27634301 Free PMC article.

2

Acridine Derivatives as Inhibitors of the IRE1α-XBP1 Pathway Are Cytotoxic to Human Multiple Myeloma.

Jiang D, Tam AB, Alagappan M, Hay MP, Gupta A, Kozak MM, Solow-Cordero DE, Lum PY, Denko NC, Giaccia AJ, Le QT, Niwa M, Koong AC. Jiang D, et al. Among authors: giaccia aj. Mol Cancer Ther. 2016 Sep;15(9):2055-65. doi: 10.1158/1535-7163.MCT-15-1023. Epub 2016 Jun 15. Mol Cancer Ther. 2016. PMID: 27307600 Free PMC article.

3

A Human Genome-Wide RNAi Screen Reveals Diverse Modulators that Mediate IRE1α-XBP1 Activation.

Yang Z, Zhang J, Jiang D, Khatri P, Solow-Cordero DE, Toesca DAS, Koumenis C, Denko NC, Giaccia AJ, Le QT, Koong AC. Yang Z, et al. Among authors: giaccia aj. Mol Cancer Res. 2018 May;16(5):745-753. doi: 10.1158/1541-7786.MCR-17-0307. Epub 2018 Feb 9. Mol Cancer Res. 2018. PMID: 29440447 Free PMC article.

4

The RGD domain of human osteopontin promotes tumor growth and metastasis through activation of survival pathways.

Courter D, Cao H, Kwok S, Kong C, Banh A, Kuo P, Bouley DM, Vice C, Brustugun OT, Denko NC, Koong AC, Giaccia A, Le QT. Courter D, et al. PLoS One. 2010 Mar 10;5(3):e9633. doi: 10.1371/journal.pone.0009633. PLoS One. 2010. PMID: 20224789 Free PMC article.

5

Measuring the Impact of Microenvironmental Conditions on Mitochondrial Dehydrogenase Activity in Cultured Cells.

Sun RC, Koong A, Giaccia A, Denko NC. Sun RC, et al. Adv Exp Med Biol. 2016;899:113-20. doi: 10.1007/978-3-319-26666-4_7. Adv Exp Med Biol. 2016. PMID: 27325264 Free PMC article.

6

XBP1 is essential for survival under hypoxic conditions and is required for tumor growth.

Romero-Ramirez L, Cao H, Nelson D, Hammond E, Lee AH, Yoshida H, Mori K, Glimcher LH, Denko NC, Giaccia AJ, Le QT, Koong AC. Romero-Ramirez L, et al. Among authors: giaccia aj. Cancer Res. 2004 Sep 1;64(17):5943-7. doi: 10.1158/0008-5472.CAN-04-1606. Cancer Res. 2004. PMID: 15342372

7

Hypoxia upregulates osteopontin expression in NIH-3T3 cells via a Ras-activated enhancer.

Zhu Y, Denhardt DT, Cao H, Sutphin PD, Koong AC, Giaccia AJ, Le QT. Zhu Y, et al. Among authors: giaccia aj. Oncogene. 2005 Sep 29;24(43):6555-63. doi: 10.1038/sj.onc.1208800. Oncogene. 2005. PMID: 16007184

8

Papaverine and its derivatives radiosensitize solid tumors by inhibiting mitochondrial metabolism.

Benej M, Hong X, Vibhute S, Scott S, Wu J, Graves E, Le QT, Koong AC, Giaccia AJ, Yu B, Chen CS, Papandreou I, Denko NC. Benej M, et al. Among authors: giaccia aj. Proc Natl Acad Sci U S A. 2018 Oct 16;115(42):10756-10761. doi: 10.1073/pnas.1808945115. Epub 2018 Sep 10. Proc Natl Acad Sci U S A. 2018. PMID: 30201710 Free PMC article.

9

Hypoxia links ATR and p53 through replication arrest.

Hammond EM, Denko NC, Dorie MJ, Abraham RT, Giaccia AJ. Hammond EM, et al. Among authors: giaccia aj. Mol Cell Biol. 2002 Mar;22(6):1834-43. doi: 10.1128/MCB.22.6.1834-1843.2002. Mol Cell Biol. 2002. PMID: 11865061 Free PMC article.

10

Therapeutic exploitation of the physiological and molecular genetic alterations in head and neck cancer.

Le QT, Giaccia AJ. Le QT, et al. Among authors: giaccia aj. Clin Cancer Res. 2003 Oct 1;9(12):4287-95. Clin Cancer Res. 2003. PMID: 14555497 Review.

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