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Wnt6 regulates epithelial cell differentiation and is dysregulated in renal fibrosis.
Beaton H, Andrews D, Parsons M, Murphy M, Gaffney A, Kavanagh D, McKay GJ, Maxwell AP, Taylor CT, Cummins EP, Godson C, Higgins DF, Murphy P, Crean J. Beaton H, et al. Among authors: andrews d. Am J Physiol Renal Physiol. 2016 Jul 1;311(1):F35-45. doi: 10.1152/ajprenal.00136.2016. Epub 2016 Apr 27. Am J Physiol Renal Physiol. 2016. PMID: 27122540 Free article.
Unravelling the transcriptional responses of TGF-β: Smad3 and EZH2 constitute a regulatory switch that controls neuroretinal epithelial cell fate specification.
Andrews D, Oliviero G, De Chiara L, Watson A, Rochford E, Wynne K, Kennedy C, Clerkin S, Doyle B, Godson C, Connell P, O'Brien C, Cagney G, Crean J. Andrews D, et al. FASEB J. 2019 May;33(5):6667-6681. doi: 10.1096/fj.201800566RR. Epub 2019 Feb 19. FASEB J. 2019. PMID: 30779601
We propose that the interaction between Smad3 and EZH2 targets the core polycomb assembly to defined regions of the genome to regulate transcriptional repression and forms a molecular switch that controls promoter access through epigenetic mechanisms leading to gene silencing.- …
We propose that the interaction between Smad3 and EZH2 targets the core polycomb assembly to defined regions of the genome to regulate trans …
A Novel Role for FERM Domain-Containing Protein 3 in CKD.
Kennedy C, Doyle R, Gough O, Mcevoy C, McAnallen S, Hughes M, Sheng X, Crifo B, Andrews D, Gaffney A, Rodriguez J, Kennedy S, Dillon E, Crean D, Zhang W, Yi Z, Nair V, Susztak K, Hirschhorn J, Florez J, Groop PH, Sandholm N, Kretzler M, McKay GJ, McKnight AJ, Maxwell AP, Matallanas D, Dorman A, Martin F, Conlon PJ, Sadlier DM, Brennan E, Godson C; Genie Consortium. Kennedy C, et al. Among authors: andrews d. Kidney360. 2024 Dec 1;5(12):1799-1812. doi: 10.34067/KID.0000000602. Epub 2024 Oct 16. Kidney360. 2024. PMID: 39450948 Free PMC article.
IHG-1 increases mitochondrial fusion and bioenergetic function.
Hickey FB, Corcoran JB, Griffin B, Bhreathnach U, Mortiboys H, Reid HM, Andrews D, Byrne S, Furlong F, Martin F, Godson C, Murphy M. Hickey FB, et al. Among authors: andrews d. Diabetes. 2014 Dec;63(12):4314-25. doi: 10.2337/db13-1256. Epub 2014 Jul 9. Diabetes. 2014. PMID: 25008184
Epigenome-wide meta-analysis identifies DNA methylation biomarkers associated with diabetic kidney disease.
Smyth LJ, Dahlström EH, Syreeni A, Kerr K, Kilner J, Doyle R, Brennan E, Nair V, Fermin D, Nelson RG, Looker HC, Wooster C, Andrews D, Anderson K, McKay GJ, Cole JB, Salem RM, Conlon PJ, Kretzler M, Hirschhorn JN, Sadlier D, Godson C, Florez JC; GENIE consortium; Forsblom C, Maxwell AP, Groop PH, Sandholm N, McKnight AJ. Smyth LJ, et al. Among authors: andrews d. Nat Commun. 2022 Dec 22;13(1):7891. doi: 10.1038/s41467-022-34963-6. Nat Commun. 2022. PMID: 36550108 Free PMC article.
1,261 results