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Page 1
Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia.
Sykes DB, Kfoury YS, Mercier FE, Wawer MJ, Law JM, Haynes MK, Lewis TA, Schajnovitz A, Jain E, Lee D, Meyer H, Pierce KA, Tolliday NJ, Waller A, Ferrara SJ, Eheim AL, Stoeckigt D, Maxcy KL, Cobert JM, Bachand J, Szekely BA, Mukherjee S, Sklar LA, Kotz JD, Clish CB, Sadreyev RI, Clemons PA, Janzer A, Schreiber SL, Scadden DT. Sykes DB, et al. Cell. 2016 Sep 22;167(1):171-186.e15. doi: 10.1016/j.cell.2016.08.057. Epub 2016 Sep 15. Cell. 2016. PMID: 27641501 Free PMC article.
The hematopoietic stem cell niche.
Park D, Sykes DB, Scadden DT. Park D, et al. Among authors: sykes db. Front Biosci (Landmark Ed). 2012 Jan 1;17(1):30-9. doi: 10.2741/3913. Front Biosci (Landmark Ed). 2012. PMID: 22201730 Free PMC article. Review.
Niche-Based Screening in Multiple Myeloma Identifies a Kinesin-5 Inhibitor with Improved Selectivity over Hematopoietic Progenitors.
Chattopadhyay S, Stewart AL, Mukherjee S, Huang C, Hartwell KA, Miller PG, Subramanian R, Carmody LC, Yusuf RZ, Sykes DB, Paulk J, Vetere A, Vallet S, Santo L, Cirstea DD, Hideshima T, Dančík V, Majireck MM, Hussain MM, Singh S, Quiroz R, Iaconelli J, Karmacharya R, Tolliday NJ, Clemons PA, Moore MAS, Stern AM, Shamji AF, Ebert BL, Golub TR, Raje NS, Scadden DT, Schreiber SL. Chattopadhyay S, et al. Among authors: sykes db. Cell Rep. 2015 Feb 10;10(5):755-770. doi: 10.1016/j.celrep.2015.01.017. Epub 2015 Feb 5. Cell Rep. 2015. PMID: 25660025 Free PMC article.
Non-genotoxic conditioning for hematopoietic stem cell transplantation using a hematopoietic-cell-specific internalizing immunotoxin.
Palchaudhuri R, Saez B, Hoggatt J, Schajnovitz A, Sykes DB, Tate TA, Czechowicz A, Kfoury Y, Ruchika F, Rossi DJ, Verdine GL, Mansour MK, Scadden DT. Palchaudhuri R, et al. Among authors: sykes db. Nat Biotechnol. 2016 Jul;34(7):738-45. doi: 10.1038/nbt.3584. Epub 2016 Jun 6. Nat Biotechnol. 2016. PMID: 27272386 Free PMC article.
Bone marrow-derived immature myeloid cells are a main source of circulating suPAR contributing to proteinuric kidney disease.
Hahm E, Wei C, Fernandez I, Li J, Tardi NJ, Tracy M, Wadhwani S, Cao Y, Peev V, Zloza A, Lusciks J, Hayek SS, O'Connor C, Bitzer M, Gupta V, Sever S, Sykes DB, Scadden DT, Reiser J. Hahm E, et al. Among authors: sykes db. Nat Med. 2017 Jan;23(1):100-106. doi: 10.1038/nm.4242. Epub 2016 Dec 12. Nat Med. 2017. PMID: 27941791 Free PMC article.
The metabolic regulator mTORC1 controls terminal myeloid differentiation.
Lee PY, Sykes DB, Ameri S, Kalaitzidis D, Charles JF, Nelson-Maney N, Wei K, Cunin P, Morris A, Cardona AE, Root DE, Scadden DT, Nigrovic PA. Lee PY, et al. Among authors: sykes db. Sci Immunol. 2017 May 26;2(11):eaam6641. doi: 10.1126/sciimmunol.aam6641. Sci Immunol. 2017. PMID: 28763796 Free PMC article.
130 results