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Metformin treatment results in distinctive skeletal muscle mitochondrial remodeling in rats with different intrinsic aerobic capacities.
Bubak MP, Davidyan A, O'Reilly CL, Mondal SA, Keast J, Doidge SM, Borowik AK, Taylor ME, Volovičeva E, Kinter MT, Britton SL, Koch LG, Stout MB, Lewis TL Jr, Miller BF. Bubak MP, et al. Among authors: lewis tl jr. Aging Cell. 2024 Sep;23(9):e14235. doi: 10.1111/acel.14235. Epub 2024 Jun 24. Aging Cell. 2024. PMID: 38923664 Free PMC article.
Activity-dependent compartmentalization of dendritic mitochondria morphology through local regulation of fusion-fission balance in neurons in vivo.
Virga DM, Hamilton S, Osei B, Morgan A, Kneis P, Zamponi E, Park NJ, Hewitt VL, Zhang D, Gonzalez KC, Russell FM, Grahame Hardie D, Prudent J, Bloss E, Losonczy A, Polleux F, Lewis TL Jr. Virga DM, et al. Among authors: lewis tl jr. Nat Commun. 2024 Mar 8;15(1):2142. doi: 10.1038/s41467-024-46463-w. Nat Commun. 2024. PMID: 38459070 Free PMC article.
Most axonal mitochondria in cortical pyramidal neurons lack mitochondrial DNA and consume ATP.
Hirabayashi Y, Lewis TL Jr, Du Y, Virga DM, Decker AM, Coceano G, Alvelid J, Paul MA, Hamilton S, Kneis P, Takahashi Y, Gaublomme JT, Testa I, Polleux F. Hirabayashi Y, et al. Among authors: lewis tl jr. bioRxiv [Preprint]. 2024 Feb 13:2024.02.12.579972. doi: 10.1101/2024.02.12.579972. bioRxiv. 2024. PMID: 38405915 Free PMC article. Preprint.
Neuronal deletion of MnSOD in mice leads to demyelination, inflammation and progressive paralysis that mimics phenotypes associated with progressive multiple sclerosis.
Bhaskaran S, Kumar G, Thadathil N, Piekarz KM, Mohammed S, Lopez SD, Qaisar R, Walton D, Brown JL, Murphy A, Smith N, Saunders D, Beckstead MJ, Plafker S, Lewis TL Jr, Towner R, Deepa SS, Richardson A, Axtell RC, Van Remmen H. Bhaskaran S, et al. Among authors: lewis tl jr. Redox Biol. 2023 Feb;59:102550. doi: 10.1016/j.redox.2022.102550. Epub 2022 Nov 26. Redox Biol. 2023. PMID: 36470129 Free PMC article.
27 results