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Synthesis of a selective HDAC6 inhibitor active in neuroblasts.
Zwick V, Simões-Pires CA, Nurisso A, Petit C, Dos Santos Passos C, Randazzo GM, Martinet N, Bertrand P, Cuendet M. Zwick V, et al. Bioorg Med Chem Lett. 2016 Oct 15;26(20):4955-4959. doi: 10.1016/j.bmcl.2016.09.011. Epub 2016 Sep 7. Bioorg Med Chem Lett. 2016. PMID: 27650925
Aurones as histone deacetylase inhibitors: identification of key features.
Zwick V, Chatzivasileiou AO, Deschamps N, Roussaki M, Simões-Pires CA, Nurisso A, Denis I, Blanquart C, Martinet N, Carrupt PA, Detsi A, Cuendet M. Zwick V, et al. Bioorg Med Chem Lett. 2014 Dec 1;24(23):5497-501. doi: 10.1016/j.bmcl.2014.10.019. Epub 2014 Oct 13. Bioorg Med Chem Lett. 2014. PMID: 25455492
Cross metathesis with hydroxamate and benzamide BOC-protected alkenes to access HDAC inhibitors and their biological evaluation highlighted intrinsic activity of BOC-protected dihydroxamates.
Zwick V, Nurisso A, Simões-Pires C, Bouchet S, Martinet N, Lehotzky A, Ovadi J, Cuendet M, Blanquart C, Bertrand P. Zwick V, et al. Bioorg Med Chem Lett. 2016 Jan 1;26(1):154-9. doi: 10.1016/j.bmcl.2015.11.011. Epub 2015 Nov 11. Bioorg Med Chem Lett. 2016. PMID: 26611919
11 results