Bourguet W - Search Results

1

Fragment-based discovery of a new family of non-peptidic small-molecule cyclophilin inhibitors with potent antiviral activities.

Ahmed-Belkacem A, Colliandre L, Ahnou N, Nevers Q, Gelin M, Bessin Y, Brillet R, Cala O, Douguet D, Bourguet W, Krimm I, Pawlotsky JM, Guichou JF. Ahmed-Belkacem A, et al. Among authors: bourguet w. Nat Commun. 2016 Sep 22;7:12777. doi: 10.1038/ncomms12777. Nat Commun. 2016. PMID: 27652979 Free PMC article.

2

Characterization of the interaction between retinoic acid receptor/retinoid X receptor (RAR/RXR) heterodimers and transcriptional coactivators through structural and fluorescence anisotropy studies.

Pogenberg V, Guichou JF, Vivat-Hannah V, Kammerer S, Pérez E, Germain P, de Lera AR, Gronemeyer H, Royer CA, Bourguet W. Pogenberg V, et al. Among authors: bourguet w. J Biol Chem. 2005 Jan 14;280(2):1625-33. doi: 10.1074/jbc.M409302200. Epub 2004 Nov 4. J Biol Chem. 2005. PMID: 15528208 Free article.

3

Discovery of a highly active ligand of human pregnane x receptor: a case study from pharmacophore modeling and virtual screening to "in vivo" biological activity.

Lemaire G, Benod C, Nahoum V, Pillon A, Boussioux AM, Guichou JF, Subra G, Pascussi JM, Bourguet W, Chavanieu A, Balaguer P. Lemaire G, et al. Among authors: bourguet w. Mol Pharmacol. 2007 Sep;72(3):572-81. doi: 10.1124/mol.106.033415. Epub 2007 Jun 15. Mol Pharmacol. 2007. PMID: 17573484

4

N-1H-benzimidazol-5-ylbenzenesulfonamide derivatives as potent hPXR agonists.

Benod C, Subra G, Nahoum V, Mallavialle A, Guichou JF, Milhau J, Roblés S, Bourguet W, Pascussi JM, Balaguer P, Chavanieu A. Benod C, et al. Among authors: bourguet w. Bioorg Med Chem. 2008 Apr 1;16(7):3537-49. doi: 10.1016/j.bmc.2008.02.020. Epub 2008 Feb 13. Bioorg Med Chem. 2008. PMID: 18304819

5

Osh4p exchanges sterols for phosphatidylinositol 4-phosphate between lipid bilayers.

de Saint-Jean M, Delfosse V, Douguet D, Chicanne G, Payrastre B, Bourguet W, Antonny B, Drin G. de Saint-Jean M, et al. Among authors: bourguet w. J Cell Biol. 2011 Dec 12;195(6):965-78. doi: 10.1083/jcb.201104062. J Cell Biol. 2011. PMID: 22162133 Free PMC article.

6

Combining 'dry' co-crystallization and in situ diffraction to facilitate ligand screening by X-ray crystallography.

Gelin M, Delfosse V, Allemand F, Hoh F, Sallaz-Damaz Y, Pirocchi M, Bourguet W, Ferrer JL, Labesse G, Guichou JF. Gelin M, et al. Among authors: bourguet w. Acta Crystallogr D Biol Crystallogr. 2015 Aug;71(Pt 8):1777-87. doi: 10.1107/S1399004715010342. Epub 2015 Jul 31. Acta Crystallogr D Biol Crystallogr. 2015. PMID: 26249358

7

Structure-Based and Knowledge-Informed Design of B-Raf Inhibitors Devoid of Deleterious PXR Binding.

Schneider M, Delfosse V, Gelin M, Grimaldi M, Granell M, Heriaud L, Pons JL, Cohen Gonsaud M, Balaguer P, Bourguet W, Labesse G. Schneider M, et al. Among authors: bourguet w. J Med Chem. 2022 Jan 27;65(2):1552-1566. doi: 10.1021/acs.jmedchem.1c01354. Epub 2021 Dec 27. J Med Chem. 2022. PMID: 34958586

8

Synergistic activation of human pregnane X receptor by binary cocktails of pharmaceutical and environmental compounds.

Delfosse V, Dendele B, Huet T, Grimaldi M, Boulahtouf A, Gerbal-Chaloin S, Beucher B, Roecklin D, Muller C, Rahmani R, Cavaillès V, Daujat-Chavanieu M, Vivat V, Pascussi JM, Balaguer P, Bourguet W. Delfosse V, et al. Among authors: bourguet w. Nat Commun. 2015 Sep 3;6:8089. doi: 10.1038/ncomms9089. Nat Commun. 2015. PMID: 26333997 Free PMC article.

9

Cryo-EM structure of the agonist-bound Hsp90-XAP2-AHR cytosolic complex.

Gruszczyk J, Grandvuillemin L, Lai-Kee-Him J, Paloni M, Savva CG, Germain P, Grimaldi M, Boulahtouf A, Kwong HS, Bous J, Ancelin A, Bechara C, Barducci A, Balaguer P, Bourguet W. Gruszczyk J, et al. Among authors: bourguet w. Nat Commun. 2022 Nov 16;13(1):7010. doi: 10.1038/s41467-022-34773-w. Nat Commun. 2022. PMID: 36385050 Free PMC article.

10

Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-alpha.

Bourguet W, Ruff M, Chambon P, Gronemeyer H, Moras D. Bourguet W, et al. Nature. 1995 Jun 1;375(6530):377-82. doi: 10.1038/375377a0. Nature. 1995. PMID: 7760929

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