Guo H - Search Results

1

Tankyrase inhibition promotes a stable human naïve pluripotent state with improved functionality.

Zimmerlin L, Park TS, Huo JS, Verma K, Pather SR, Talbot CC Jr, Agarwal J, Steppan D, Zhang YW, Considine M, Guo H, Zhong X, Gutierrez C, Cope L, Canto-Soler MV, Friedman AD, Baylin SB, Zambidis ET. Zimmerlin L, et al. Among authors: guo h. Development. 2016 Dec 1;143(23):4368-4380. doi: 10.1242/dev.138982. Epub 2016 Sep 22. Development. 2016. PMID: 27660325 Free PMC article.

2

Phosphorylation of RUNX1 by cyclin-dependent kinase reduces direct interaction with HDAC1 and HDAC3.

Guo H, Friedman AD. Guo H, et al. J Biol Chem. 2011 Jan 7;286(1):208-15. doi: 10.1074/jbc.M110.149013. Epub 2010 Nov 8. J Biol Chem. 2011. PMID: 21059642 Free PMC article.

3

The Cebpa +37-kb enhancer directs transgene expression to myeloid progenitors and to long-term hematopoietic stem cells.

Guo H, Ma O, Friedman AD. Guo H, et al. J Leukoc Biol. 2014 Sep;96(3):419-26. doi: 10.1189/jlb.2AB0314-145R. Epub 2014 May 27. J Leukoc Biol. 2014. PMID: 24868087 Free PMC article.

4

The +37 kb Cebpa Enhancer Is Critical for Cebpa Myeloid Gene Expression and Contains Functional Sites that Bind SCL, GATA2, C/EBPα, PU.1, and Additional Ets Factors.

Cooper S, Guo H, Friedman AD. Cooper S, et al. Among authors: guo h. PLoS One. 2015 May 4;10(5):e0126385. doi: 10.1371/journal.pone.0126385. eCollection 2015. PLoS One. 2015. PMID: 25938608 Free PMC article.

5

In Vivo Deletion of the Cebpa +37 kb Enhancer Markedly Reduces Cebpa mRNA in Myeloid Progenitors but Not in Non-Hematopoietic Tissues to Impair Granulopoiesis.

Guo H, Cooper S, Friedman AD. Guo H, et al. PLoS One. 2016 Mar 3;11(3):e0150809. doi: 10.1371/journal.pone.0150809. eCollection 2016. PLoS One. 2016. PMID: 26937964 Free PMC article.

6

Cyclin-dependent kinase phosphorylation of RUNX1/AML1 on 3 sites increases transactivation potency and stimulates cell proliferation.

Zhang L, Fried FB, Guo H, Friedman AD. Zhang L, et al. Among authors: guo h. Blood. 2008 Feb 1;111(3):1193-200. doi: 10.1182/blood-2007-08-109702. Epub 2007 Nov 14. Blood. 2008. PMID: 18003885 Free PMC article.

7

Runx1 deletion or dominant inhibition reduces Cebpa transcription via conserved promoter and distal enhancer sites to favor monopoiesis over granulopoiesis.

Guo H, Ma O, Speck NA, Friedman AD. Guo H, et al. Blood. 2012 May 10;119(19):4408-18. doi: 10.1182/blood-2011-12-397091. Epub 2012 Mar 26. Blood. 2012. PMID: 22451420 Free PMC article.

8

Progression from the Common Lymphoid Progenitor to B/Myeloid PreproB and ProB Precursors during B Lymphopoiesis Requires C/EBPα.

Guo H, Barberi T, Suresh R, Friedman AD. Guo H, et al. J Immunol. 2018 Sep 15;201(6):1692-1704. doi: 10.4049/jimmunol.1800244. Epub 2018 Jul 30. J Immunol. 2018. PMID: 30061199 Free PMC article.

9

Granulopoiesis requires increased C/EBPα compared to monopoiesis, correlated with elevated Cebpa in immature G-CSF receptor versus M-CSF receptor expressing cells.

Ma O, Hong S, Guo H, Ghiaur G, Friedman AD. Ma O, et al. Among authors: guo h. PLoS One. 2014 Apr 21;9(4):e95784. doi: 10.1371/journal.pone.0095784. eCollection 2014. PLoS One. 2014. PMID: 24752325 Free PMC article.

10

Runx1 Phosphorylation by Src Increases Trans-activation via Augmented Stability, Reduced Histone Deacetylase (HDAC) Binding, and Increased DNA Affinity, and Activated Runx1 Favors Granulopoiesis.

Leong WY, Guo H, Ma O, Huang H, Cantor AB, Friedman AD. Leong WY, et al. Among authors: guo h. J Biol Chem. 2016 Jan 8;291(2):826-36. doi: 10.1074/jbc.M115.674234. Epub 2015 Nov 23. J Biol Chem. 2016. PMID: 26598521 Free PMC article.

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