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The root causes of pharmacodynamic assay failure.
Ferry-Galow KV, Makhlouf HR, Wilsker DF, Lawrence SM, Pfister TD, Marrero AM, Bigelow KM, Yutzy WH, Ji JJ, Butcher DO, Gouker BA, Kummar S, Chen AP, Kinders RJ, Parchment RE, Doroshow JH. Ferry-Galow KV, et al. Among authors: butcher do. Semin Oncol. 2016 Aug;43(4):484-91. doi: 10.1053/j.seminoncol.2016.06.006. Epub 2016 Jun 15. Semin Oncol. 2016. PMID: 27663480 Review.
Decoding NADPH oxidase 4 expression in human tumors.
Meitzler JL, Makhlouf HR, Antony S, Wu Y, Butcher D, Jiang G, Juhasz A, Lu J, Dahan I, Jansen-Dürr P, Pircher H, Shah AM, Roy K, Doroshow JH. Meitzler JL, et al. Redox Biol. 2017 Oct;13:182-195. doi: 10.1016/j.redox.2017.05.016. Epub 2017 May 26. Redox Biol. 2017. PMID: 28578276 Free PMC article.
NADPH oxidase 5 (NOX5)-induced reactive oxygen signaling modulates normoxic HIF-1α and p27Kip1 expression in malignant melanoma and other human tumors.
Antony S, Jiang G, Wu Y, Meitzler JL, Makhlouf HR, Haines DC, Butcher D, Hoon DS, Ji J, Zhang Y, Juhasz A, Lu J, Liu H, Dahan I, Konate M, Roy KK, Doroshow JH. Antony S, et al. Mol Carcinog. 2017 Dec;56(12):2643-2662. doi: 10.1002/mc.22708. Epub 2017 Aug 30. Mol Carcinog. 2017. PMID: 28762556 Free PMC article.
NADPH oxidase 1 is highly expressed in human large and small bowel cancers.
Lu J, Jiang G, Wu Y, Antony S, Meitzler JL, Juhasz A, Liu H, Roy K, Makhlouf H, Chuaqui R, Butcher D, Konaté MM, Doroshow JH. Lu J, et al. PLoS One. 2020 May 19;15(5):e0233208. doi: 10.1371/journal.pone.0233208. eCollection 2020. PLoS One. 2020. PMID: 32428030 Free PMC article.
Systemic Nos2 Depletion and Cox inhibition limits TNBC disease progression and alters lymphoid cell spatial orientation and density.
Somasundaram V, Ridnour LA, Cheng RY, Walke AJ, Kedei N, Bhattacharyya DD, Wink AL, Edmondson EF, Butcher D, Warner AC, Dorsey TH, Scheiblin DA, Heinz W, Bryant RJ, Kinders RJ, Lipkowitz S, Wong ST, Pore M, Hewitt SM, McVicar DW, Anderson SK, Chang J, Glynn SA, Ambs S, Lockett SJ, Wink DA. Somasundaram V, et al. Redox Biol. 2022 Dec;58:102529. doi: 10.1016/j.redox.2022.102529. Epub 2022 Nov 9. Redox Biol. 2022. PMID: 36375380 Free PMC article.
Interferon-gamma is quintessential for NOS2 and COX2 expression in ER- breast tumors that lead to poor outcome.
Cheng RYS, Ridnour LA, Wink AL, Gonzalez AL, Femino EL, Rittscher H, Somasundaram V, Heinz WF, Coutinho L, Rangel MC, Edmondson EF, Butcher D, Kinders RJ, Li X, Wong STC, McVicar DW, Anderson SK, Pore M, Hewitt SM, Billiar TR, Glynn SA, Chang JC, Lockett SJ, Ambs S, Wink DA. Cheng RYS, et al. Cell Death Dis. 2023 May 11;14(5):319. doi: 10.1038/s41419-023-05834-9. Cell Death Dis. 2023. PMID: 37169743 Free PMC article.
47 results