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Liver Microvascular Injury and Thrombocytopenia of Antibody-Calicheamicin Conjugates in Cynomolgus Monkeys-Mechanism and Monitoring.
Guffroy M, Falahatpisheh H, Biddle K, Kreeger J, Obert L, Walters K, Goldstein R, Boucher G, Coskran T, Reagan W, Sullivan D, Huang C, Sokolowski S, Giovanelli R, Gerber HP, Finkelstein M, Khan N. Guffroy M, et al. Among authors: reagan w. Clin Cancer Res. 2017 Apr 1;23(7):1760-1770. doi: 10.1158/1078-0432.CCR-16-0939. Epub 2016 Sep 28. Clin Cancer Res. 2017. PMID: 27683177
The inhibin B response in male rats treated with two drug candidates.
Chapin RE, Alvey JD, Goldstein RA, Dokmanovich MG, Reagan WJ, Johnson K, Geoly FJ. Chapin RE, et al. Birth Defects Res B Dev Reprod Toxicol. 2013 Feb;98(1):54-62. doi: 10.1002/bdrb.21040. Epub 2013 Jan 24. Birth Defects Res B Dev Reprod Toxicol. 2013. PMID: 23348891
Comprehensive Nonclinical Safety Assessment of Nirmatrelvir Supporting Timely Development of the SARS-COV-2 Antiviral Therapeutic, Paxlovid™.
Sathish JG, Bhatt S, DaSilva JK, Flynn D, Jenkinson S, Kalgutkar AS, Liu M, Manickam B, Pinkstaff J, Reagan WJ, Shirai N, Shoieb AM, Sirivelu M, Vispute S, Vitsky A, Walters K, Wisialowski TA, Updyke LW. Sathish JG, et al. Among authors: reagan wj. Int J Toxicol. 2022 Aug;41(4):276-290. doi: 10.1177/10915818221095489. Epub 2022 May 21. Int J Toxicol. 2022. PMID: 35603517 Free PMC article.
The use of emerging safety biomarkers in nonclinical and clinical safety assessment - The current and future state: An IQ DruSafe industry survey.
Zabka TS, Burkhardt J, Reagan WJ, Gautier JC, Glaab WE, Guffroy M, Harding J, Brees D, McDuffie E, Ramaiah L, Schultze AE, Smith JD, Wolfreys A, Dalmas DA. Zabka TS, et al. Among authors: reagan wj. Regul Toxicol Pharmacol. 2021 Mar;120:104857. doi: 10.1016/j.yrtph.2020.104857. Epub 2020 Dec 31. Regul Toxicol Pharmacol. 2021. PMID: 33387566 Free article.
Summary of the HESI consortium studies exploring circulating inhibin B as a potential biomarker of testis damage in the rat.
Chapin R, Weinbauer G, Thibodeau MS, Sonee M, Saldutti LP, Reagan WJ, Potter D, Moffit JS, Laffan S, Kim JH, Goldstein RA, Erdos Z, Enright BP, Coulson M, Breslin WJ. Chapin R, et al. Birth Defects Res B Dev Reprod Toxicol. 2013 Feb;98(1):110-8. doi: 10.1002/bdrb.21041. Epub 2013 Jan 30. Birth Defects Res B Dev Reprod Toxicol. 2013. PMID: 23364877
72 results