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Hypoxia-inducible factor-2α plays a role in mediating oesophagitis in GORD.
Huo X, Agoston AT, Dunbar KB, Cipher DJ, Zhang X, Yu C, Cheng E, Zhang Q, Pham TH, Tambar UK, Bruick RK, Wang DH, Odze RD, Spechler SJ, Souza RF. Huo X, et al. Among authors: bruick rk. Gut. 2017 Sep;66(9):1542-1554. doi: 10.1136/gutjnl-2016-312595. Epub 2016 Sep 30. Gut. 2017. PMID: 27694141 Free PMC article. Clinical Trial.
Allosteric inhibition of hypoxia inducible factor-2 with small molecules.
Scheuermann TH, Li Q, Ma HW, Key J, Zhang L, Chen R, Garcia JA, Naidoo J, Longgood J, Frantz DE, Tambar UK, Gardner KH, Bruick RK. Scheuermann TH, et al. Among authors: bruick rk. Nat Chem Biol. 2013 Apr;9(4):271-6. doi: 10.1038/nchembio.1185. Epub 2013 Feb 24. Nat Chem Biol. 2013. PMID: 23434853 Free PMC article.
Isoform-Selective and Stereoselective Inhibition of Hypoxia Inducible Factor-2.
Scheuermann TH, Stroud D, Sleet CE, Bayeh L, Shokri C, Wang H, Caldwell CG, Longgood J, MacMillan JB, Bruick RK, Gardner KH, Tambar UK. Scheuermann TH, et al. Among authors: bruick rk. J Med Chem. 2015 Aug 13;58(15):5930-41. doi: 10.1021/acs.jmedchem.5b00529. Epub 2015 Jul 30. J Med Chem. 2015. PMID: 26226049
Development of inhibitors of the PAS-B domain of the HIF-2α transcription factor.
Rogers JL, Bayeh L, Scheuermann TH, Longgood J, Key J, Naidoo J, Melito L, Shokri C, Frantz DE, Bruick RK, Gardner KH, MacMillan JB, Tambar UK. Rogers JL, et al. Among authors: bruick rk. J Med Chem. 2013 Feb 28;56(4):1739-47. doi: 10.1021/jm301847z. Epub 2013 Feb 18. J Med Chem. 2013. PMID: 23363003 Free PMC article.
Functions of the Per/ARNT/Sim domains of the hypoxia-inducible factor.
Yang J, Zhang L, Erbel PJ, Gardner KH, Ding K, Garcia JA, Bruick RK. Yang J, et al. Among authors: bruick rk. J Biol Chem. 2005 Oct 28;280(43):36047-54. doi: 10.1074/jbc.M501755200. Epub 2005 Aug 29. J Biol Chem. 2005. PMID: 16129688 Free article.
52 results