van der Merwe PA - Search Results

1

Architecture of a minimal signaling pathway explains the T-cell response to a 1 million-fold variation in antigen affinity and dose.

Lever M, Lim HS, Kruger P, Nguyen J, Trendel N, Abu-Shah E, Maini PK, van der Merwe PA, Dushek O. Lever M, et al. Among authors: van der merwe pa. Proc Natl Acad Sci U S A. 2016 Oct 25;113(43):E6630-E6638. doi: 10.1073/pnas.1608820113. Epub 2016 Oct 4. Proc Natl Acad Sci U S A. 2016. PMID: 27702900 Free PMC article.

2

Immunology: how do T cells recognize antigen?

Choudhuri K, Kearney A, Bakker TR, van der Merwe PA. Choudhuri K, et al. Among authors: van der merwe pa. Curr Biol. 2005 May 24;15(10):R382-5. doi: 10.1016/j.cub.2005.05.001. Curr Biol. 2005. PMID: 15916940 Free article. Review.

3

Dependence of T cell antigen recognition on T cell receptor-peptide MHC confinement time.

Aleksic M, Dushek O, Zhang H, Shenderov E, Chen JL, Cerundolo V, Coombs D, van der Merwe PA. Aleksic M, et al. Among authors: van der merwe pa. Immunity. 2010 Feb 26;32(2):163-74. doi: 10.1016/j.immuni.2009.11.013. Epub 2010 Feb 4. Immunity. 2010. PMID: 20137987 Free PMC article.

4

Mechanisms for T cell receptor triggering.

van der Merwe PA, Dushek O. van der Merwe PA, et al. Nat Rev Immunol. 2011 Jan;11(1):47-55. doi: 10.1038/nri2887. Epub 2010 Dec 3. Nat Rev Immunol. 2011. PMID: 21127503 Review.

5

Ultrasensitivity in multisite phosphorylation of membrane-anchored proteins.

Dushek O, van der Merwe PA, Shahrezaei V. Dushek O, et al. Among authors: van der merwe pa. Biophys J. 2011 Mar 2;100(5):1189-97. doi: 10.1016/j.bpj.2011.01.060. Biophys J. 2011. PMID: 21354391 Free PMC article.

6

Antigen potency and maximal efficacy reveal a mechanism of efficient T cell activation.

Dushek O, Aleksic M, Wheeler RJ, Zhang H, Cordoba SP, Peng YC, Chen JL, Cerundolo V, Dong T, Coombs D, van der Merwe PA. Dushek O, et al. Among authors: van der merwe pa. Sci Signal. 2011 Jun 7;4(176):ra39. doi: 10.1126/scisignal.2001430. Sci Signal. 2011. PMID: 21653229 Free PMC article.

7

Basic residues in the T-cell receptor ζ cytoplasmic domain mediate membrane association and modulate signaling.

Zhang H, Cordoba SP, Dushek O, van der Merwe PA. Zhang H, et al. Among authors: van der merwe pa. Proc Natl Acad Sci U S A. 2011 Nov 29;108(48):19323-8. doi: 10.1073/pnas.1108052108. Epub 2011 Nov 14. Proc Natl Acad Sci U S A. 2011. PMID: 22084078 Free PMC article.

8

Kinetics and mechanics of two-dimensional interactions between T cell receptors and different activating ligands.

Robert P, Aleksic M, Dushek O, Cerundolo V, Bongrand P, van der Merwe PA. Robert P, et al. Among authors: van der merwe pa. Biophys J. 2012 Jan 18;102(2):248-57. doi: 10.1016/j.bpj.2011.11.4018. Biophys J. 2012. PMID: 22339861 Free PMC article.

9

Mechanical modulation of receptor-ligand interactions at cell-cell interfaces.

Allard JF, Dushek O, Coombs D, van der Merwe PA. Allard JF, et al. Among authors: van der merwe pa. Biophys J. 2012 Mar 21;102(6):1265-73. doi: 10.1016/j.bpj.2012.02.006. Epub 2012 Mar 20. Biophys J. 2012. PMID: 22455909 Free PMC article.

10

Non-catalytic tyrosine-phosphorylated receptors.

Dushek O, Goyette J, van der Merwe PA. Dushek O, et al. Among authors: van der merwe pa. Immunol Rev. 2012 Nov;250(1):258-76. doi: 10.1111/imr.12008. Immunol Rev. 2012. PMID: 23046135 Review.

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