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Ataluren stimulates ribosomal selection of near-cognate tRNAs to promote nonsense suppression.
Roy B, Friesen WJ, Tomizawa Y, Leszyk JD, Zhuo J, Johnson B, Dakka J, Trotta CR, Xue X, Mutyam V, Keeling KM, Mobley JA, Rowe SM, Bedwell DM, Welch EM, Jacobson A. Roy B, et al. Among authors: xue x. Proc Natl Acad Sci U S A. 2016 Nov 1;113(44):12508-12513. doi: 10.1073/pnas.1605336113. Epub 2016 Oct 4. Proc Natl Acad Sci U S A. 2016. PMID: 27702906 Free PMC article.
Therapeutics based on stop codon readthrough.
Keeling KM, Xue X, Gunn G, Bedwell DM. Keeling KM, et al. Among authors: xue x. Annu Rev Genomics Hum Genet. 2014;15:371-94. doi: 10.1146/annurev-genom-091212-153527. Epub 2014 Apr 18. Annu Rev Genomics Hum Genet. 2014. PMID: 24773318 Free PMC article. Review.
Discovery of Clinically Approved Agents That Promote Suppression of Cystic Fibrosis Transmembrane Conductance Regulator Nonsense Mutations.
Mutyam V, Du M, Xue X, Keeling KM, White EL, Bostwick JR, Rasmussen L, Liu B, Mazur M, Hong JS, Falk Libby E, Liang F, Shang H, Mense M, Suto MJ, Bedwell DM, Rowe SM. Mutyam V, et al. Among authors: xue x. Am J Respir Crit Care Med. 2016 Nov 1;194(9):1092-1103. doi: 10.1164/rccm.201601-0154OC. Am J Respir Crit Care Med. 2016. PMID: 27104944 Free PMC article.
The minor gentamicin complex component, X2, is a potent premature stop codon readthrough molecule with therapeutic potential.
Friesen WJ, Johnson B, Sierra J, Zhuo J, Vazirani P, Xue X, Tomizawa Y, Baiazitov R, Morrill C, Ren H, Babu S, Moon YC, Branstrom A, Mollin A, Hedrick J, Sheedy J, Elfring G, Weetall M, Colacino JM, Welch EM, Peltz SW. Friesen WJ, et al. Among authors: xue x. PLoS One. 2018 Oct 25;13(10):e0206158. doi: 10.1371/journal.pone.0206158. eCollection 2018. PLoS One. 2018. PMID: 30359426 Free PMC article.
Ataluren suppresses a premature termination codon in an MPS I-H mouse.
Wang D, Xue X, Gunn G, Du M, Siddiqui A, Weetall M, Keeling KM. Wang D, et al. Among authors: xue x. J Mol Med (Berl). 2022 Aug;100(8):1223-1235. doi: 10.1007/s00109-022-02232-0. Epub 2022 Jul 20. J Mol Med (Berl). 2022. PMID: 35857082 Free PMC article.
Synthetic aminoglycosides efficiently suppress cystic fibrosis transmembrane conductance regulator nonsense mutations and are enhanced by ivacaftor.
Xue X, Mutyam V, Tang L, Biswas S, Du M, Jackson LA, Dai Y, Belakhov V, Shalev M, Chen F, Schacht J, J Bridges R, Baasov T, Hong J, Bedwell DM, Rowe SM. Xue X, et al. Am J Respir Cell Mol Biol. 2014 Apr;50(4):805-16. doi: 10.1165/rcmb.2013-0282OC. Am J Respir Cell Mol Biol. 2014. PMID: 24251786 Free PMC article.
5,609 results