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A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms.
Jones AM, Westwood IM, Osborne JD, Matthews TP, Cheeseman MD, Rowlands MG, Jeganathan F, Burke R, Lee D, Kadi N, Liu M, Richards M, McAndrew C, Yahya N, Dobson SE, Jones K, Workman P, Collins I, van Montfort RL. Jones AM, et al. Among authors: kadi n. Sci Rep. 2016 Oct 6;6:34701. doi: 10.1038/srep34701. Sci Rep. 2016. PMID: 27708405 Free PMC article.
Exploiting Protein Conformational Change to Optimize Adenosine-Derived Inhibitors of HSP70.
Cheeseman MD, Westwood IM, Barbeau O, Rowlands M, Dobson S, Jones AM, Jeganathan F, Burke R, Kadi N, Workman P, Collins I, van Montfort RL, Jones K. Cheeseman MD, et al. Among authors: kadi n. J Med Chem. 2016 May 26;59(10):4625-36. doi: 10.1021/acs.jmedchem.5b02001. Epub 2016 May 11. J Med Chem. 2016. PMID: 27119979 Free PMC article.
Purification, crystallization and data collection of Pectobacterium chrysanthemi AcsD, a type A siderophore synthetase.
McMahon SA, Oke M, Liu H, Johnson KA, Carter L, Kadi N, White MF, Challis GL, Naismith JH. McMahon SA, et al. Among authors: kadi n. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Nov 1;64(Pt 11):1052-5. doi: 10.1107/S1744309108032132. Epub 2008 Oct 31. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008. PMID: 18997340 Free PMC article.
The Scottish Structural Proteomics Facility: targets, methods and outputs.
Oke M, Carter LG, Johnson KA, Liu H, McMahon SA, Yan X, Kerou M, Weikart ND, Kadi N, Sheikh MA, Schmelz S, Dorward M, Zawadzki M, Cozens C, Falconer H, Powers H, Overton IM, van Niekerk CA, Peng X, Patel P, Garrett RA, Prangishvili D, Botting CH, Coote PJ, Dryden DT, Barton GJ, Schwarz-Linek U, Challis GL, Taylor GL, White MF, Naismith JH. Oke M, et al. Among authors: kadi n. J Struct Funct Genomics. 2010 Jun;11(2):167-80. doi: 10.1007/s10969-010-9090-y. Epub 2010 Apr 24. J Struct Funct Genomics. 2010. PMID: 20419351 Free PMC article.
61 results