Huth F - Search Results

1

Improvement of the chemical inhibition phenotyping assay by cross-reactivity correction.

Njuguna NM, Umehara KI, Huth F, Schiller H, Chibale K, Camenisch G. Njuguna NM, et al. Among authors: huth f. Drug Metab Pers Ther. 2016 Dec 1;31(4):221-228. doi: 10.1515/dmpt-2016-0028. Drug Metab Pers Ther. 2016. PMID: 27718490

2

Esterase phenotyping in human liver in vitro: specificity of carboxylesterase inhibitors.

Umehara K, Zollinger M, Kigondu E, Witschi M, Juif C, Huth F, Schiller H, Chibale K, Camenisch G. Umehara K, et al. Among authors: huth f. Xenobiotica. 2016 Oct;46(10):862-7. doi: 10.3109/00498254.2015.1133867. Epub 2016 Feb 18. Xenobiotica. 2016. PMID: 26887925

3

Estimation of fractions metabolized by hepatic CYP enzymes using a concept of inter-system extrapolation factors (ISEFs) - a comparison with the chemical inhibition method.

Umehara KI, Huth F, Gu H, Schiller H, Heimbach T, He H. Umehara KI, et al. Among authors: huth f. Drug Metab Pers Ther. 2017 Dec 20;32(4):191-200. doi: 10.1515/dmpt-2017-0024. Drug Metab Pers Ther. 2017. PMID: 29176011

4

In vitro studies and in silico predictions of fluconazole and CYP2C9 genetic polymorphism impact on siponimod metabolism and pharmacokinetics.

Jin Y, Borell H, Gardin A, Ufer M, Huth F, Camenisch G. Jin Y, et al. Among authors: huth f. Eur J Clin Pharmacol. 2018 Apr;74(4):455-464. doi: 10.1007/s00228-017-2404-2. Epub 2017 Dec 22. Eur J Clin Pharmacol. 2018. PMID: 29273968 Free PMC article.

5

Verification of a physiologically based pharmacokinetic model of ritonavir to estimate drug-drug interaction potential of CYP3A4 substrates.

Umehara KI, Huth F, Won CS, Heimbach T, He H. Umehara KI, et al. Among authors: huth f. Biopharm Drug Dispos. 2018 Mar;39(3):152-163. doi: 10.1002/bdd.2122. Biopharm Drug Dispos. 2018. PMID: 29451681

6

Examining P-gp efflux kinetics guided by the BDDCS - Rational selection of in vitro assay designs and mathematical models.

Riede J, Umehara KI, Schweigler P, Huth F, Schiller H, Camenisch G, Poller B. Riede J, et al. Among authors: huth f. Eur J Pharm Sci. 2019 Apr 30;132:132-141. doi: 10.1016/j.ejps.2019.03.005. Epub 2019 Mar 9. Eur J Pharm Sci. 2019. PMID: 30857914

7

Drug-drug interaction (DDI) assessments of ruxolitinib, a dual substrate of CYP3A4 and CYP2C9, using a verified physiologically based pharmacokinetic (PBPK) model to support regulatory submissions.

Umehara K, Huth F, Jin Y, Schiller H, Aslanis V, Heimbach T, He H. Umehara K, et al. Among authors: huth f. Drug Metab Pers Ther. 2019 May 30;34(2):/j/dmdi.2019.34.issue-2/dmpt-2018-0042/dmpt-2018-0042.xml. doi: 10.1515/dmpt-2018-0042. Drug Metab Pers Ther. 2019. PMID: 31145690

8

Prediction of the Impact of Cytochrome P450 2C9 Genotypes on the Drug-Drug Interaction Potential of Siponimod With Physiologically-Based Pharmacokinetic Modeling: A Comprehensive Approach for Drug Label Recommendations.

Huth F, Gardin A, Umehara K, He H. Huth F, et al. Clin Pharmacol Ther. 2019 Nov;106(5):1113-1124. doi: 10.1002/cpt.1547. Epub 2019 Aug 11. Clin Pharmacol Ther. 2019. PMID: 31199498 Free PMC article.

9

Multiple administrations of fluconazole increase plasma exposure to ruxolitinib in healthy adult subjects.

Aslanis V, Umehara K, Huth F, Ouatas T, Bharathy S, Butler AA, Zhou W, Gadbaw B. Aslanis V, et al. Among authors: huth f. Cancer Chemother Pharmacol. 2019 Oct;84(4):749-757. doi: 10.1007/s00280-019-03907-1. Epub 2019 Jul 19. Cancer Chemother Pharmacol. 2019. PMID: 31324935 Clinical Trial.

10

Physiologically-Based Pharmacokinetic Models for Evaluating Membrane Transporter Mediated Drug-Drug Interactions: Current Capabilities, Case Studies, Future Opportunities, and Recommendations.

Taskar KS, Pilla Reddy V, Burt H, Posada MM, Varma M, Zheng M, Ullah M, Emami Riedmaier A, Umehara KI, Snoeys J, Nakakariya M, Chu X, Beneton M, Chen Y, Huth F, Narayanan R, Mukherjee D, Dixit V, Sugiyama Y, Neuhoff S. Taskar KS, et al. Among authors: huth f. Clin Pharmacol Ther. 2020 May;107(5):1082-1115. doi: 10.1002/cpt.1693. Epub 2019 Dec 31. Clin Pharmacol Ther. 2020. PMID: 31628859 Free PMC article. Review.

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