Walensky LD - Search Results

1

Mechanistic validation of a clinical lead stapled peptide that reactivates p53 by dual HDM2 and HDMX targeting.

Wachter F, Morgan AM, Godes M, Mourtada R, Bird GH, Walensky LD. Wachter F, et al. Among authors: walensky ld. Oncogene. 2017 Apr;36(15):2184-2190. doi: 10.1038/onc.2016.361. Epub 2016 Oct 10. Oncogene. 2017. PMID: 27721413 Free PMC article.

2

Reactivation of the p53 tumor suppressor pathway by a stapled p53 peptide.

Bernal F, Tyler AF, Korsmeyer SJ, Walensky LD, Verdine GL. Bernal F, et al. Among authors: walensky ld. J Am Chem Soc. 2007 Mar 7;129(9):2456-7. doi: 10.1021/ja0693587. Epub 2007 Feb 7. J Am Chem Soc. 2007. PMID: 17284038 Free PMC article. No abstract available.

3

Dual role of proapoptotic BAD in insulin secretion and beta cell survival.

Danial NN, Walensky LD, Zhang CY, Choi CS, Fisher JK, Molina AJ, Datta SR, Pitter KL, Bird GH, Wikstrom JD, Deeney JT, Robertson K, Morash J, Kulkarni A, Neschen S, Kim S, Greenberg ME, Corkey BE, Shirihai OS, Shulman GI, Lowell BB, Korsmeyer SJ. Danial NN, et al. Among authors: walensky ld. Nat Med. 2008 Feb;14(2):144-53. doi: 10.1038/nm1717. Epub 2008 Jan 27. Nat Med. 2008. PMID: 18223655 Free PMC article.

4

Synthesis and biophysical characterization of stabilized alpha-helices of BCL-2 domains.

Bird GH, Bernal F, Pitter K, Walensky LD. Bird GH, et al. Among authors: walensky ld. Methods Enzymol. 2008;446:369-86. doi: 10.1016/S0076-6879(08)01622-4. Methods Enzymol. 2008. PMID: 18603134 Free PMC article.

5

BAX activation is initiated at a novel interaction site.

Gavathiotis E, Suzuki M, Davis ML, Pitter K, Bird GH, Katz SG, Tu HC, Kim H, Cheng EH, Tjandra N, Walensky LD. Gavathiotis E, et al. Among authors: walensky ld. Nature. 2008 Oct 23;455(7216):1076-81. doi: 10.1038/nature07396. Nature. 2008. PMID: 18948948 Free PMC article.

6

Hydrocarbon double-stapling remedies the proteolytic instability of a lengthy peptide therapeutic.

Bird GH, Madani N, Perry AF, Princiotto AM, Supko JG, He X, Gavathiotis E, Sodroski JG, Walensky LD. Bird GH, et al. Among authors: walensky ld. Proc Natl Acad Sci U S A. 2010 Aug 10;107(32):14093-8. doi: 10.1073/pnas.1002713107. Epub 2010 Jul 21. Proc Natl Acad Sci U S A. 2010. PMID: 20660316 Free PMC article.

7

BH3-triggered structural reorganization drives the activation of proapoptotic BAX.

Gavathiotis E, Reyna DE, Davis ML, Bird GH, Walensky LD. Gavathiotis E, et al. Among authors: walensky ld. Mol Cell. 2010 Nov 12;40(3):481-92. doi: 10.1016/j.molcel.2010.10.019. Mol Cell. 2010. PMID: 21070973 Free PMC article.

8

A stapled p53 helix overcomes HDMX-mediated suppression of p53.

Bernal F, Wade M, Godes M, Davis TN, Whitehead DG, Kung AL, Wahl GM, Walensky LD. Bernal F, et al. Among authors: walensky ld. Cancer Cell. 2010 Nov 16;18(5):411-22. doi: 10.1016/j.ccr.2010.10.024. Cancer Cell. 2010. PMID: 21075307 Free PMC article.

9

Photoreactive stapled BH3 peptides to dissect the BCL-2 family interactome.

Braun CR, Mintseris J, Gavathiotis E, Bird GH, Gygi SP, Walensky LD. Braun CR, et al. Among authors: walensky ld. Chem Biol. 2010 Dec 22;17(12):1325-33. doi: 10.1016/j.chembiol.2010.09.015. Chem Biol. 2010. PMID: 21168768 Free PMC article.

10

Characterization of a core fragment of the rhesus monkey TRIM5α protein.

Kar AK, Mao Y, Bird G, Walensky L, Sodroski J. Kar AK, et al. BMC Biochem. 2011 Jan 4;12:1. doi: 10.1186/1471-2091-12-1. BMC Biochem. 2011. PMID: 21205312 Free PMC article.

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