Brown H - Search Results

1

Relationship between mutant Cu/Zn superoxide dismutase 1 maturation and inclusion formation in cell models.

Ayers JI, McMahon B, Gill S, Lelie HL, Fromholt S, Brown H, Valentine JS, Whitelegge JP, Borchelt DR. Ayers JI, et al. Among authors: brown h. J Neurochem. 2017 Jan;140(1):140-150. doi: 10.1111/jnc.13864. Epub 2016 Nov 25. J Neurochem. 2017. PMID: 27727458 Free PMC article.

2

Distinctive features of the D101N and D101G variants of superoxide dismutase 1; two mutations that produce rapidly progressing motor neuron disease.

Ayers J, Lelie H, Workman A, Prudencio M, Brown H, Fromholt S, Valentine J, Whitelegge J, Borchelt D. Ayers J, et al. Among authors: brown h. J Neurochem. 2014 Jan;128(2):305-14. doi: 10.1111/jnc.12451. Epub 2013 Oct 21. J Neurochem. 2014. PMID: 24032979 Free PMC article.

3

An analysis of interactions between fluorescently-tagged mutant and wild-type SOD1 in intracellular inclusions.

Qualls DA, Crosby K, Brown H, Borchelt DR. Qualls DA, et al. Among authors: brown h. PLoS One. 2013 Dec 31;8(12):e83981. doi: 10.1371/journal.pone.0083981. eCollection 2013. PLoS One. 2013. PMID: 24391857 Free PMC article.

4

Direct and indirect mechanisms for wild-type SOD1 to enhance the toxicity of mutant SOD1 in bigenic transgenic mice.

Xu G, Ayers JI, Roberts BL, Brown H, Fromholt S, Green C, Borchelt DR. Xu G, et al. Among authors: brown h. Hum Mol Genet. 2015 Feb 15;24(4):1019-35. doi: 10.1093/hmg/ddu517. Epub 2014 Oct 9. Hum Mol Genet. 2015. PMID: 25305079 Free PMC article.

5

Substantially elevating the levels of αB-crystallin in spinal motor neurons of mutant SOD1 mice does not significantly delay paralysis or attenuate mutant protein aggregation.

Xu G, Fromholt S, Ayers JI, Brown H, Siemienski Z, Crosby KW, Mayer CA, Janus C, Borchelt DR. Xu G, et al. Among authors: brown h. J Neurochem. 2015 May;133(3):452-64. doi: 10.1111/jnc.13022. Epub 2015 Jan 26. J Neurochem. 2015. PMID: 25557022 Free PMC article.

6

Loss of charge mutations in solvent exposed Lys residues of superoxide dismutase 1 do not induce inclusion formation in cultured cell models.

Crosby K, Crown AM, Roberts BL, Brown H, Ayers JI, Borchelt DR. Crosby K, et al. Among authors: brown h. PLoS One. 2018 Nov 6;13(11):e0206751. doi: 10.1371/journal.pone.0206751. eCollection 2018. PLoS One. 2018. PMID: 30399166 Free PMC article.

7

Experimental Mutations in Superoxide Dismutase 1 Provide Insight into Potential Mechanisms Involved in Aberrant Aggregation in Familial Amyotrophic Lateral Sclerosis.

Crown AM, Roberts BL, Crosby K, Brown H, Ayers JI, Hart PJ, Borchelt DR. Crown AM, et al. Among authors: brown h. G3 (Bethesda). 2019 Mar 7;9(3):719-728. doi: 10.1534/g3.118.200787. G3 (Bethesda). 2019. PMID: 30622123 Free PMC article.

8

Tryptophan residue 32 in human Cu-Zn superoxide dismutase modulates prion-like propagation and strain selection.

Crown A, McAlary L, Fagerli E, Brown H, Yerbury JJ, Galaleldeen A, Cashman NR, Borchelt DR, Ayers JI. Crown A, et al. Among authors: brown h. PLoS One. 2020 Jan 30;15(1):e0227655. doi: 10.1371/journal.pone.0227655. eCollection 2020. PLoS One. 2020. PMID: 31999698 Free PMC article.

9

A novel variant of human superoxide dismutase 1 harboring amyotrophic lateral sclerosis-associated and experimental mutations in metal-binding residues and free cysteines lacks toxicity in vivo.

Prudencio M, Lelie H, Brown HH, Whitelegge JP, Valentine JS, Borchelt DR. Prudencio M, et al. Among authors: brown hh. J Neurochem. 2012 May;121(3):475-85. doi: 10.1111/j.1471-4159.2012.07690.x. Epub 2012 Mar 20. J Neurochem. 2012. PMID: 22332887 Free PMC article.

10

Role of disulfide cross-linking of mutant SOD1 in the formation of inclusion-body-like structures.

Roberts BL, Patel K, Brown HH, Borchelt DR. Roberts BL, et al. Among authors: brown hh. PLoS One. 2012;7(10):e47838. doi: 10.1371/journal.pone.0047838. Epub 2012 Oct 31. PLoS One. 2012. PMID: 23118898 Free PMC article.

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