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Sustained virologic control in SIV+ macaques after antiretroviral and α4β7 antibody therapy.
Byrareddy SN, Arthos J, Cicala C, Villinger F, Ortiz KT, Little D, Sidell N, Kane MA, Yu J, Jones JW, Santangelo PJ, Zurla C, McKinnon LR, Arnold KB, Woody CE, Walter L, Roos C, Noll A, Van Ryk D, Jelicic K, Cimbro R, Gumber S, Reid MD, Adsay V, Amancha PK, Mayne AE, Parslow TG, Fauci AS, Ansari AA. Byrareddy SN, et al. Among authors: little d. Science. 2016 Oct 14;354(6309):197-202. doi: 10.1126/science.aag1276. Science. 2016. PMID: 27738167 Free PMC article.
Early treatment of SIV+ macaques with an α4β7 mAb alters virus distribution and preserves CD4+ T cells in later stages of infection.
Santangelo PJ, Cicala C, Byrareddy SN, Ortiz KT, Little D, Lindsay KE, Gumber S, Hong JJ, Jelicic K, Rogers KA, Zurla C, Villinger F, Ansari AA, Fauci AS, Arthos J. Santangelo PJ, et al. Among authors: little d. Mucosal Immunol. 2018 May;11(3):932-946. doi: 10.1038/mi.2017.112. Epub 2017 Dec 20. Mucosal Immunol. 2018. PMID: 29346349 Free PMC article.
Targeting α4β7 integrin reduces mucosal transmission of simian immunodeficiency virus and protects gut-associated lymphoid tissue from infection.
Byrareddy SN, Kallam B, Arthos J, Cicala C, Nawaz F, Hiatt J, Kersh EN, McNicholl JM, Hanson D, Reimann KA, Brameier M, Walter L, Rogers K, Mayne AE, Dunbar P, Villinger T, Little D, Parslow TG, Santangelo PJ, Villinger F, Fauci AS, Ansari AA. Byrareddy SN, et al. Among authors: little d. Nat Med. 2014 Dec;20(12):1397-400. doi: 10.1038/nm.3715. Epub 2014 Nov 24. Nat Med. 2014. PMID: 25419708 Free PMC article.
In vivo administration of a JAK3 inhibitor during acute SIV infection leads to significant increases in viral load during chronic infection.
Takahashi Y, Byrareddy SN, Albrecht C, Brameier M, Walter L, Mayne AE, Dunbar P, Russo R, Little DM, Villinger T, Khowawisetsut L, Pattanapanyasat K, Villinger F, Ansari AA. Takahashi Y, et al. PLoS Pathog. 2014 Mar 6;10(3):e1003929. doi: 10.1371/journal.ppat.1003929. eCollection 2014 Mar. PLoS Pathog. 2014. PMID: 24603870 Free PMC article.
Blocking of α4β7 gut-homing integrin during acute infection leads to decreased plasma and gastrointestinal tissue viral loads in simian immunodeficiency virus-infected rhesus macaques.
Ansari AA, Reimann KA, Mayne AE, Takahashi Y, Stephenson ST, Wang R, Wang X, Li J, Price AA, Little DM, Zaidi M, Lyles R, Villinger F. Ansari AA, et al. J Immunol. 2011 Jan 15;186(2):1044-59. doi: 10.4049/jimmunol.1003052. Epub 2010 Dec 13. J Immunol. 2011. PMID: 21149598 Free PMC article.
1,154 results