Brady SF - Search Results

1

Discovery of MRSA active antibiotics using primary sequence from the human microbiome.

Chu J, Vila-Farres X, Inoyama D, Ternei M, Cohen LJ, Gordon EA, Reddy BV, Charlop-Powers Z, Zebroski HA, Gallardo-Macias R, Jaskowski M, Satish S, Park S, Perlin DS, Freundlich JS, Brady SF. Chu J, et al. Among authors: brady sf. Nat Chem Biol. 2016 Dec;12(12):1004-1006. doi: 10.1038/nchembio.2207. Epub 2016 Oct 17. Nat Chem Biol. 2016. PMID: 27748750 Free PMC article.

2

Construction of soil environmental DNA cosmid libraries and screening for clones that produce biologically active small molecules.

Brady SF. Brady SF. Nat Protoc. 2007;2(5):1297-305. doi: 10.1038/nprot.2007.195. Nat Protoc. 2007. PMID: 17546026

3

Fluostatins produced by the heterologous expression of a TAR reassembled environmental DNA derived type II PKS gene cluster.

Feng Z, Kim JH, Brady SF. Feng Z, et al. Among authors: brady sf. J Am Chem Soc. 2010 Sep 1;132(34):11902-3. doi: 10.1021/ja104550p. J Am Chem Soc. 2010. PMID: 20690632 Free PMC article.

4

Recent application of metagenomic approaches toward the discovery of antimicrobials and other bioactive small molecules.

Banik JJ, Brady SF. Banik JJ, et al. Among authors: brady sf. Curr Opin Microbiol. 2010 Oct;13(5):603-9. doi: 10.1016/j.mib.2010.08.012. Epub 2010 Sep 29. Curr Opin Microbiol. 2010. PMID: 20884282 Free PMC article. Review.

5

Functional analysis of environmental DNA-derived type II polyketide synthases reveals structurally diverse secondary metabolites.

Feng Z, Kallifidas D, Brady SF. Feng Z, et al. Among authors: brady sf. Proc Natl Acad Sci U S A. 2011 Aug 2;108(31):12629-34. doi: 10.1073/pnas.1103921108. Epub 2011 Jul 18. Proc Natl Acad Sci U S A. 2011. PMID: 21768346 Free PMC article.

6

Environmental DNA-encoded antibiotics fasamycins A and B inhibit FabF in type II fatty acid biosynthesis.

Feng Z, Chakraborty D, Dewell SB, Reddy BV, Brady SF. Feng Z, et al. Among authors: brady sf. J Am Chem Soc. 2012 Feb 15;134(6):2981-7. doi: 10.1021/ja207662w. Epub 2012 Feb 2. J Am Chem Soc. 2012. PMID: 22224500 Free PMC article.

7

Natural product biosynthetic gene diversity in geographically distinct soil microbiomes.

Reddy BV, Kallifidas D, Kim JH, Charlop-Powers Z, Feng Z, Brady SF. Reddy BV, et al. Among authors: brady sf. Appl Environ Microbiol. 2012 May;78(10):3744-52. doi: 10.1128/AEM.00102-12. Epub 2012 Mar 16. Appl Environ Microbiol. 2012. PMID: 22427492 Free PMC article.

8

Biocatalysts and small molecule products from metagenomic studies.

Iqbal HA, Feng Z, Brady SF. Iqbal HA, et al. Among authors: brady sf. Curr Opin Chem Biol. 2012 Apr;16(1-2):109-16. doi: 10.1016/j.cbpa.2012.02.015. Epub 2012 Mar 26. Curr Opin Chem Biol. 2012. PMID: 22455793 Free PMC article. Review.

9

Malleilactone, a polyketide synthase-derived virulence factor encoded by the cryptic secondary metabolome of Burkholderia pseudomallei group pathogens.

Biggins JB, Ternei MA, Brady SF. Biggins JB, et al. Among authors: brady sf. J Am Chem Soc. 2012 Aug 15;134(32):13192-5. doi: 10.1021/ja3052156. Epub 2012 Aug 1. J Am Chem Soc. 2012. PMID: 22765305 Free PMC article.

10

Selective enrichment of environmental DNA libraries for genes encoding nonribosomal peptides and polyketides by phosphopantetheine transferase-dependent complementation of siderophore biosynthesis.

Charlop-Powers Z, Banik JJ, Owen JG, Craig JW, Brady SF. Charlop-Powers Z, et al. Among authors: brady sf. ACS Chem Biol. 2013 Jan 18;8(1):138-43. doi: 10.1021/cb3004918. Epub 2012 Oct 26. ACS Chem Biol. 2013. PMID: 23072412 Free PMC article.

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