Kelly GL - Search Results

1

The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models.

Kotschy A, Szlavik Z, Murray J, Davidson J, Maragno AL, Le Toumelin-Braizat G, Chanrion M, Kelly GL, Gong JN, Moujalled DM, Bruno A, Csekei M, Paczal A, Szabo ZB, Sipos S, Radics G, Proszenyak A, Balint B, Ondi L, Blasko G, Robertson A, Surgenor A, Dokurno P, Chen I, Matassova N, Smith J, Pedder C, Graham C, Studeny A, Lysiak-Auvity G, Girard AM, Gravé F, Segal D, Riffkin CD, Pomilio G, Galbraith LC, Aubrey BJ, Brennan MS, Herold MJ, Chang C, Guasconi G, Cauquil N, Melchiore F, Guigal-Stephan N, Lockhart B, Colland F, Hickman JA, Roberts AW, Huang DC, Wei AH, Strasser A, Lessene G, Geneste O. Kotschy A, et al. Among authors: kelly gl. Nature. 2016 Oct 27;538(7626):477-482. doi: 10.1038/nature19830. Epub 2016 Oct 19. Nature. 2016. PMID: 27760111

2

The essential role of evasion from cell death in cancer.

Kelly GL, Strasser A. Kelly GL, et al. Adv Cancer Res. 2011;111:39-96. doi: 10.1016/B978-0-12-385524-4.00002-7. Adv Cancer Res. 2011. PMID: 21704830 Free PMC article. Review.

3

Targeting of MCL-1 kills MYC-driven mouse and human lymphomas even when they bear mutations in p53.

Kelly GL, Grabow S, Glaser SP, Fitzsimmons L, Aubrey BJ, Okamoto T, Valente LJ, Robati M, Tai L, Fairlie WD, Lee EF, Lindstrom MS, Wiman KG, Huang DC, Bouillet P, Rowe M, Rickinson AB, Herold MJ, Strasser A. Kelly GL, et al. Genes Dev. 2014 Jan 1;28(1):58-70. doi: 10.1101/gad.232009.113. Genes Dev. 2014. PMID: 24395247 Free PMC article.

4

An inducible lentiviral guide RNA platform enables the identification of tumor-essential genes and tumor-promoting mutations in vivo.

Aubrey BJ, Kelly GL, Kueh AJ, Brennan MS, O'Connor L, Milla L, Wilcox S, Tai L, Strasser A, Herold MJ. Aubrey BJ, et al. Among authors: kelly gl. Cell Rep. 2015 Mar 3;10(8):1422-32. doi: 10.1016/j.celrep.2015.02.002. Epub 2015 Feb 26. Cell Rep. 2015. PMID: 25732831 Free article.

5

Impact of the combined loss of BOK, BAX and BAK on the hematopoietic system is slightly more severe than compound loss of BAX and BAK.

Ke F, Grabow S, Kelly GL, Lin A, O'Reilly LA, Strasser A. Ke F, et al. Among authors: kelly gl. Cell Death Dis. 2015 Oct 22;6(10):e1938. doi: 10.1038/cddis.2015.304. Cell Death Dis. 2015. PMID: 26492371 Free PMC article.

6

The Transcription Factor ASCIZ and Its Target DYNLL1 Are Essential for the Development and Expansion of MYC-Driven B Cell Lymphoma.

Wong DM, Li L, Jurado S, King A, Bamford R, Wall M, Walia MK, Kelly GL, Walkley CR, Tarlinton DM, Strasser A, Heierhorst J. Wong DM, et al. Among authors: kelly gl. Cell Rep. 2016 Feb 16;14(6):1488-1499. doi: 10.1016/j.celrep.2016.01.012. Epub 2016 Jan 28. Cell Rep. 2016. PMID: 26832406 Free article.

7

Therapeutic Response to Non-genotoxic Activation of p53 by Nutlin3a Is Driven by PUMA-Mediated Apoptosis in Lymphoma Cells.

Valente LJ, Aubrey BJ, Herold MJ, Kelly GL, Happo L, Scott CL, Newbold A, Johnstone RW, Huang DC, Vassilev LT, Strasser A. Valente LJ, et al. Among authors: kelly gl. Cell Rep. 2016 Mar 1;14(8):1858-66. doi: 10.1016/j.celrep.2016.01.059. Epub 2016 Feb 18. Cell Rep. 2016. PMID: 26904937 Free article.

8

Critical B-lymphoid cell intrinsic role of endogenous MCL-1 in c-MYC-induced lymphomagenesis.

Grabow S, Kelly GL, Delbridge AR, Kelly PN, Bouillet P, Adams JM, Strasser A. Grabow S, et al. Among authors: kelly gl, kelly pn. Cell Death Dis. 2016 Mar 10;7(3):e2132. doi: 10.1038/cddis.2016.43. Cell Death Dis. 2016. PMID: 26962682 Free PMC article.

9

BET inhibition represses miR17-92 to drive BIM-initiated apoptosis of normal and transformed hematopoietic cells.

Xu Z, Sharp PP, Yao Y, Segal D, Ang CH, Khaw SL, Aubrey BJ, Gong J, Kelly GL, Herold MJ, Strasser A, Roberts AW, Alexander WS, Burns CJ, Huang DC, Glaser SP. Xu Z, et al. Among authors: kelly gl. Leukemia. 2016 Jul;30(7):1531-41. doi: 10.1038/leu.2016.52. Epub 2016 Mar 8. Leukemia. 2016. PMID: 27055867

10

Tumor-Suppressor Functions of the TP53 Pathway.

Aubrey BJ, Strasser A, Kelly GL. Aubrey BJ, et al. Among authors: kelly gl. Cold Spring Harb Perspect Med. 2016 May 2;6(5):a026062. doi: 10.1101/cshperspect.a026062. Cold Spring Harb Perspect Med. 2016. PMID: 27141080 Free PMC article. Review.

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