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PPARγ-coactivator-1α gene transfer reduces neuronal loss and amyloid-β generation by reducing β-secretase in an Alzheimer's disease model.
Katsouri L, Lim YM, Blondrath K, Eleftheriadou I, Lombardero L, Birch AM, Mirzaei N, Irvine EE, Mazarakis ND, Sastre M. Katsouri L, et al. Among authors: irvine ee. Proc Natl Acad Sci U S A. 2016 Oct 25;113(43):12292-12297. doi: 10.1073/pnas.1606171113. Epub 2016 Oct 10. Proc Natl Acad Sci U S A. 2016. PMID: 27791018 Free PMC article.
Modulation of SF1 Neuron Activity Coordinately Regulates Both Feeding Behavior and Associated Emotional States.
Viskaitis P, Irvine EE, Smith MA, Choudhury AI, Alvarez-Curto E, Glegola JA, Hardy DG, Pedroni SMA, Paiva Pessoa MR, Fernando ABP, Katsouri L, Sardini A, Ungless MA, Milligan G, Withers DJ. Viskaitis P, et al. Among authors: irvine ee. Cell Rep. 2017 Dec 19;21(12):3559-3572. doi: 10.1016/j.celrep.2017.11.089. Cell Rep. 2017. PMID: 29262334 Free PMC article.
Deletion of Irs2 reduces amyloid deposition and rescues behavioural deficits in APP transgenic mice.
Killick R, Scales G, Leroy K, Causevic M, Hooper C, Irvine EE, Choudhury AI, Drinkwater L, Kerr F, Al-Qassab H, Stephenson J, Yilmaz Z, Giese KP, Brion JP, Withers DJ, Lovestone S. Killick R, et al. Among authors: irvine ee. Biochem Biophys Res Commun. 2009 Aug 14;386(1):257-62. doi: 10.1016/j.bbrc.2009.06.032. Epub 2009 Jun 10. Biochem Biophys Res Commun. 2009. PMID: 19523444 Free PMC article.
Mechanism for long-term memory formation when synaptic strengthening is impaired.
Radwanska K, Medvedev NI, Pereira GS, Engmann O, Thiede N, Moraes MF, Villers A, Irvine EE, Maunganidze NS, Pyza EM, Ris L, Szymańska M, Lipiński M, Kaczmarek L, Stewart MG, Giese KP. Radwanska K, et al. Among authors: irvine ee. Proc Natl Acad Sci U S A. 2011 Nov 8;108(45):18471-5. doi: 10.1073/pnas.1109680108. Epub 2011 Oct 24. Proc Natl Acad Sci U S A. 2011. PMID: 22025701 Free PMC article.
56 results